STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (429 aa)    
Predicted Functional Partners:
Psta_2907
PFAM: phosphoglucose isomerase (PGI); KEGG: bsu:BSU31350 glucose-6-phosphate isomerase.
  
 0.977
Psta_0847
Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
 
 
 0.935
Psta_4392
6-phosphofructokinase; PFAM: phosphofructokinase; KEGG: pyrophosphate-dependent fructose 6-phosphate 1-phosphotransferase.
  
  
  0.920
Psta_0329
PFAM: phosphofructokinase; KEGG: gur:Gura_2657 diphosphate--fructose-6- phosphate 1-phosphotransferase.
  
  
 
0.919
Psta_1600
TIGRFAM: transketolase; PFAM: Transketolase central region; Transketolase domain protein; KEGG: bxe:Bxe_B1309 transketolase; Belongs to the transketolase family.
  
 
 0.914
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
  
 
0.913
fbp
PFAM: Inositol phosphatase/fructose-16- bisphosphatase; KEGG: hap:HAPS_1200 fructose-1,6-bisphosphatase.
    
 0.913
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.912
Psta_3461
PFAM: ROK family protein; KEGG: sde:Sde_2639 fructokinase.
    
 0.904
Psta_4651
KEGG: aba:Acid345_0569 mannose-6-phosphate isomerase; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I.
     
 0.904
Your Current Organism:
Pirellula staleyi
NCBI taxonomy Id: 530564
Other names: P. staleyi DSM 6068, Pirellula staleyi ATCC 27377, Pirellula staleyi DSM 6068, Pirellula staleyi str. DSM 6068, Pirellula staleyi strain DSM 6068
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