STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (922 aa)    
Predicted Functional Partners:
Psta_2965
KEGG: mxa:MXAN_1950 ATP-dependent DNA helicase, RecQ family; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein.
 
 0.986
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.906
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.891
Psta_2668
TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: wsu:WS1872 single-strand DNA-binding protein.
  
 
 0.847
Psta_2267
PFAM: SMC domain protein; KEGG: mxa:MXAN_4513 hypothetical protein.
  
 0.843
Psta_0145
KEGG: merozoite surface protein 3 (MSP3).
  
 0.831
Psta_0199
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: rma:Rmag_1018 glutamate synthase (ferredoxin).
  
  
 0.829
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: hypothetical protein; K01869 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.809
Psta_0042
SMART: helicase c2; DEAD-like helicase; KEGG: gme:Gmet_3167 helicase C2.
   
 0.807
Psta_2268
PFAM: metallophosphoesterase; KEGG: mxa:MXAN_4514 metallophosphoesterase.
  
 0.803
Your Current Organism:
Pirellula staleyi
NCBI taxonomy Id: 530564
Other names: P. staleyi DSM 6068, Pirellula staleyi ATCC 27377, Pirellula staleyi DSM 6068, Pirellula staleyi str. DSM 6068, Pirellula staleyi strain DSM 6068
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