Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Psta_4202PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mca:MCA2527 6-pyruvoyl tetrahydropterin synthase, putative. (169 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.994
Psta_4201
ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.965
folE
KEGG: bsu:BSU22780 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I.
  
 
 0.957
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.930
Psta_0408
Alkaline phosphatase; KEGG: bsu:BSU02620 phosphodiesterase/alkaline phosphatase D.
     
  0.900
Psta_0813
KEGG: eba:ebA362 phosphodiesterase/alkaline phosphatase D.
     
  0.900
Psta_0824
Phosphodiesterase; KEGG: rce:RC1_0026 phosphodiesterase.
     
  0.900
Psta_4266
KEGG: 6-pyruvoyl tetrahydrobiopterin synthase; K01737 6-pyruvoyl tetrahydrobiopterin synthase.
     
  0.900
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.856
Psta_1253
KEGG: afw:Anae109_3313 cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: cyclic nucleotide-binding; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SMART: cyclic nucleotide-binding.
  
 0.559
Your Current Organism:
Pirellula staleyi
NCBI taxonomy Id: 530564
Other names: P. staleyi DSM 6068, Pirellula staleyi ATCC 27377, Pirellula staleyi DSM 6068, Pirellula staleyi str. DSM 6068, Pirellula staleyi strain DSM 6068
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