node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDC00164.1 | SDC17532.1 | SAMN05421630_1018 | SAMN05421630_101699 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Polysaccharide deacetylase. | 0.794 |
SDC00164.1 | SDC74693.1 | SAMN05421630_1018 | SAMN05421630_103465 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Diguanylate cyclase (GGDEF) domain-containing protein. | 0.735 |
SDC00164.1 | SDD34041.1 | SAMN05421630_1018 | SAMN05421630_107364 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Putative hydrolase. | 0.969 |
SDC00164.1 | SDD39589.1 | SAMN05421630_1018 | SAMN05421630_10823 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Acyl transferase domain-containing protein. | 0.885 |
SDC00164.1 | hisA | SAMN05421630_1018 | SAMN05421630_107367 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.802 |
SDC00164.1 | hisE | SAMN05421630_1018 | SAMN05421630_105447 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | phosphoribosyl-ATP pyrophosphatase. | 0.763 |
SDC00164.1 | hisF | SAMN05421630_1018 | SAMN05421630_107371 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.827 |
SDC00164.1 | hisG | SAMN05421630_1018 | SAMN05421630_105446 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.765 |
SDC00164.1 | hisH | SAMN05421630_1018 | SAMN05421630_107366 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.841 |
SDC00164.1 | hisI | SAMN05421630_1018 | SAMN05421630_107372 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.776 |
SDC17532.1 | SDC00164.1 | SAMN05421630_101699 | SAMN05421630_1018 | Polysaccharide deacetylase. | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 0.794 |
SDC17532.1 | SDD39589.1 | SAMN05421630_101699 | SAMN05421630_10823 | Polysaccharide deacetylase. | Acyl transferase domain-containing protein. | 0.496 |
SDC74693.1 | SDC00164.1 | SAMN05421630_103465 | SAMN05421630_1018 | Diguanylate cyclase (GGDEF) domain-containing protein. | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 0.735 |
SDD34041.1 | SDC00164.1 | SAMN05421630_107364 | SAMN05421630_1018 | Putative hydrolase. | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 0.969 |
SDD34041.1 | hisA | SAMN05421630_107364 | SAMN05421630_107367 | Putative hydrolase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.621 |
SDD34041.1 | hisG | SAMN05421630_107364 | SAMN05421630_105446 | Putative hydrolase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.401 |
SDD34041.1 | hisH | SAMN05421630_107364 | SAMN05421630_107366 | Putative hydrolase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.746 |
SDD34041.1 | hisI | SAMN05421630_107364 | SAMN05421630_107372 | Putative hydrolase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.576 |
SDD39589.1 | SDC00164.1 | SAMN05421630_10823 | SAMN05421630_1018 | Acyl transferase domain-containing protein. | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 0.885 |
SDD39589.1 | SDC17532.1 | SAMN05421630_10823 | SAMN05421630_101699 | Acyl transferase domain-containing protein. | Polysaccharide deacetylase. | 0.496 |