STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FIC_01163DNA topoisomerase IB (poxvirus type). (368 aa)    
Predicted Functional Partners:
FIC_01164
Short-chain dehydrogenase/reductase, probable oxidoreductase.
 
 
   0.789
FIC_01276
Topoisomerase IV subunit B.
   
 
 0.724
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.724
FIC_01162
Hypothetical protein.
       0.714
FIC_01165
Hypothetical protein.
       0.701
FIC_01169
ATP-dependent DNA ligase.
 
 
 
 0.622
FIC_01168
ATP-dependent DNA ligase family protein.
 
 
 
 0.618
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.595
FIC_01166
Hypothetical protein.
       0.593
FIC_01920
Amine oxidase.
  
 
 
 0.589
Your Current Organism:
Flavobacteriaceae bacterium 351910
NCBI taxonomy Id: 531844
Other names: F. bacterium 3519-10, Flavobacteriaceae bacterium 3519-10
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.