node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKB33645.1 | SKB33665.1 | SAMN05660750_00151 | SAMN05660750_00154 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SKB33645.1 | SKB43511.1 | SAMN05660750_00151 | SAMN05660750_00638 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.903 |
SKB33645.1 | SKB91133.1 | SAMN05660750_00151 | SAMN05660750_02991 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.956 |
SKB33645.1 | SKB96455.1 | SAMN05660750_00151 | SAMN05660750_03276 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.939 |
SKB33645.1 | ilvC | SAMN05660750_00151 | SAMN05660750_00146 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
SKB33645.1 | leuA | SAMN05660750_00151 | SAMN05660750_00126 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.939 |
SKB33645.1 | leuB | SAMN05660750_00151 | SAMN05660750_00394 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.963 |
SKB33645.1 | leuC | SAMN05660750_00151 | SAMN05660750_00431 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.868 |
SKB33645.1 | leuC-2 | SAMN05660750_00151 | SAMN05660750_00639 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.867 |
SKB33645.1 | leuD | SAMN05660750_00151 | SAMN05660750_00434 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.899 |
SKB33665.1 | SKB33645.1 | SAMN05660750_00154 | SAMN05660750_00151 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SKB33665.1 | SKB43511.1 | SAMN05660750_00154 | SAMN05660750_00638 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.880 |
SKB33665.1 | SKB91133.1 | SAMN05660750_00154 | SAMN05660750_02991 | Acetolactate synthase, large subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.831 |
SKB33665.1 | SKB96455.1 | SAMN05660750_00154 | SAMN05660750_03276 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.855 |
SKB33665.1 | ilvC | SAMN05660750_00154 | SAMN05660750_00146 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
SKB33665.1 | leuA | SAMN05660750_00154 | SAMN05660750_00126 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.915 |
SKB33665.1 | leuB | SAMN05660750_00154 | SAMN05660750_00394 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.916 |
SKB33665.1 | leuC | SAMN05660750_00154 | SAMN05660750_00431 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.853 |
SKB33665.1 | leuC-2 | SAMN05660750_00154 | SAMN05660750_00639 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.851 |
SKB33665.1 | leuD | SAMN05660750_00154 | SAMN05660750_00434 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.869 |