Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (220 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.993
dnaD
DNA replication protein DnaD; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.967
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
 
 0.827
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.788
LIU_07540
Recombinase RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.742
perR
Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Fur family.
     
 0.645
mutM
5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
      
 0.627
LIU_10225
Endoribonuclease L-PSP; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.600
LIU_09505
Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.597
rlmL
RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methyltransferase superfamily.
  
    0.576
Your Current Organism:
Enterococcus durans
NCBI taxonomy Id: 53345
Other names: ATCC 19432, CCUG 7972, CIP 55.125, DSM 20633, E. durans, Enterococcus sp. VJI19, JCM 8725, LMG 10746, LMG:10746, NBRC 100479, NCDO 596, NCIMB 700596, NCTC 8307, Streptococcus durans, strain 98D
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