STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (388 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.999
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.993
OTP26357.1
Hypothetical protein.
 
 
 0.986
aroK
Hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.982
NifJ
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
   
 
 0.977
aroF
Phospho-2-dehydro-3-deoxyheptonate aldolase.
 
  
 0.976
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.966
pheA
Hypothetical protein.
 
   
 0.937
OTP25352.1
Chorismate mutase.
  
  
 0.751
OTP27325.1
Hypothetical protein.
 
   
 0.750
Your Current Organism:
Enterococcus mundtii
NCBI taxonomy Id: 53346
Other names: ATCC 43186, CCUG 18656, CFBP 4251, CIP 103010, DSM 4838, E. mundtii, Enterobacter sp. PX-E.sp.Jor, JCM 8731, LMG 10748, LMG:10748, MUTK 559, NBRC 100490, NCDO 2375, NCIMB 702375, NCTC 12363
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