Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ORA75678.1Restriction endonuclease subunit S; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)    
Predicted Functional Partners:
ORA75679.1
Restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
ORA71391.1
DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.941
ORA75800.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.901
ORA76344.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
  
 0.733
ORA71393.1
Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.703
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.684
ORA75680.1
Cell division protein DivIVA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.683
ORA75681.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.672
thyX
Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.669
ORA75941.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.663
Your Current Organism:
Mycobacterium heidelbergense
NCBI taxonomy Id: 53376
Other names: ATCC 51253, CIP 105424, DSM 44471, JCM 14842, M. heidelbergense, strain 2554/91
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