pyrH protein (Mycobacterium heidelbergense) - STRING interaction network

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pyrH

UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (277 aa)

Predicted Functional Partners:

frr

0.992

upp

0.957

pyrR

0.947

pyrF

0.946

ndk

0.945

tsf

0.940

atpH

0.940

rpsB

0.928

ORA75770.1

0.926

guaA

0.857

Your Current Organism:

Mycobacterium heidelbergense

NCBI taxonomy Id: 53376
Other names: ATCC 51253, CIP 105424, DSM 44471, JCM 14842, M. heidelbergense, strain 2554/91

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ORA75770.1	frr	BST25_04870	BST25_04875	Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.872
ORA75770.1	pyrH	BST25_04870	BST25_04880	Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family.	UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.926
ORA75770.1	tsf	BST25_04870	BST25_04905	Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family.	Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.418
atpH	frr	BST25_08075	BST25_04875	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.952
atpH	guaA	BST25_08075	BST25_16000	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.564
atpH	ndk	BST25_08075	BST25_00595	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.926
atpH	pyrH	BST25_08075	BST25_04880	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.940
atpH	rpsB	BST25_08075	BST25_04910	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family.	0.952
atpH	tsf	BST25_08075	BST25_04905	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.968
frr	ORA75770.1	BST25_04875	BST25_04870	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family.	0.872
frr	atpH	BST25_04875	BST25_08075	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	0.952
frr	guaA	BST25_04875	BST25_16000	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.661
frr	pyrH	BST25_04875	BST25_04880	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.992
frr	rpsB	BST25_04875	BST25_04910	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family.	0.985
frr	tsf	BST25_04875	BST25_04905	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.990
guaA	atpH	BST25_16000	BST25_08075	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	F0F1 ATP synthase subunit B/delta; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction; Belongs to the ATPase delta chain family.	0.564
guaA	frr	BST25_16000	BST25_04875	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.661
guaA	ndk	BST25_16000	BST25_00595	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.665
guaA	pyrF	BST25_16000	BST25_12240	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	Orotidine-5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily.	0.755
guaA	pyrH	BST25_16000	BST25_04880	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.857