Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ORA68052.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (289 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.947
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
    
 0.943
ORA68051.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.865
aspS
aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
       0.739
ORA68053.1
Deazaflavin-dependent nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.739
ORA74699.1
Alpha-ketoglutarate-dependent dioxygenase AlkB; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.713
ORA70168.1
Reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
    
 0.652
ORA74511.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.585
ORA72885.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
 0.513
cmk
Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.487
Your Current Organism:
Mycobacterium heidelbergense
NCBI taxonomy Id: 53376
Other names: ATCC 51253, CIP 105424, DSM 44471, JCM 14842, M. heidelbergense, strain 2554/91
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