STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCHydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (630 aa)    
Predicted Functional Partners:
SED45822.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.992
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.982
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.971
SED53124.1
8-oxo-dGTPase.
  
 
 0.941
SED19348.1
Sulfur carrier protein ThiS.
  
  
 0.863
SEE01647.1
Adenylyltransferase and sulfurtransferase.
 
  
 0.832
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family.
    
 0.764
SEC06761.1
Adenylyltransferase and sulfurtransferase.
 
  
 0.722
purD
Phosphoribosylamine--glycine ligase; Belongs to the GARS family.
  
 
 0.710
purM
Phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.700
Your Current Organism:
Pseudomonas anguilliseptica
NCBI taxonomy Id: 53406
Other names: ATCC 33660, CCUG 35503, CIP 106711, DSM 12111, LMG 21629, LMG:21629, P. anguilliseptica
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