| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SED16817.1 | SED16930.1 | SAMN05421553_2155 | SAMN05421553_2157 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | 0.541 |
| SED16817.1 | SEE04909.1 | SAMN05421553_2155 | SAMN05421553_3920 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.695 |
| SED16817.1 | SEE74988.1 | SAMN05421553_2155 | SAMN05421553_4993 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Homoserine dehydrogenase. | 0.776 |
| SED16817.1 | hisA | SAMN05421553_2155 | SAMN05421553_1871 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.541 |
| SED16817.1 | hisB | SAMN05421553_2155 | SAMN05421553_1868 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazoleglycerol-phosphate dehydratase. | 0.551 |
| SED16817.1 | hisF | SAMN05421553_2155 | SAMN05421553_1872 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.611 |
| SED16817.1 | hisH | SAMN05421553_2155 | SAMN05421553_1869 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.643 |
| SED16817.1 | hisZ | SAMN05421553_2155 | SAMN05421553_0727 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.771 |
| SED16817.1 | rppH | SAMN05421553_2155 | SAMN05421553_2156 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.572 |
| SED16817.1 | serC | SAMN05421553_2155 | SAMN05421553_4810 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.536 |
| SED16930.1 | SED16817.1 | SAMN05421553_2157 | SAMN05421553_2155 | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.541 |
| SED16930.1 | SEE04909.1 | SAMN05421553_2157 | SAMN05421553_3920 | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.708 |
| SED16930.1 | rppH | SAMN05421553_2157 | SAMN05421553_2156 | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.900 |
| SEE04909.1 | SED16817.1 | SAMN05421553_3920 | SAMN05421553_2155 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.695 |
| SEE04909.1 | SED16930.1 | SAMN05421553_3920 | SAMN05421553_2157 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | 0.708 |
| SEE04909.1 | SEE74988.1 | SAMN05421553_3920 | SAMN05421553_4993 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.987 |
| SEE04909.1 | rppH | SAMN05421553_3920 | SAMN05421553_2156 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.617 |
| SEE04909.1 | serC | SAMN05421553_3920 | SAMN05421553_4810 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.595 |
| SEE74988.1 | SED16817.1 | SAMN05421553_4993 | SAMN05421553_2155 | Homoserine dehydrogenase. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.776 |
| SEE74988.1 | SEE04909.1 | SAMN05421553_4993 | SAMN05421553_3920 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.987 |
