| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SED17037.1 | SED17098.1 | SAMN05421553_2159 | SAMN05421553_2160 | Uncharacterized conserved protein, contains NRDE domain. | Hypothetical protein. | 0.875 |
| SED17037.1 | SED17146.1 | SAMN05421553_2159 | SAMN05421553_2161 | Uncharacterized conserved protein, contains NRDE domain. | Hypothetical protein. | 0.745 |
| SED17037.1 | SED17486.1 | SAMN05421553_2159 | SAMN05421553_2167 | Uncharacterized conserved protein, contains NRDE domain. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.439 |
| SED17037.1 | SED25187.1 | SAMN05421553_2159 | SAMN05421553_2318 | Uncharacterized conserved protein, contains NRDE domain. | Glutamate synthase (NADPH) large subunit. | 0.532 |
| SED17037.1 | lgt | SAMN05421553_2159 | SAMN05421553_2162 | Uncharacterized conserved protein, contains NRDE domain. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.740 |
| SED17037.1 | thyA | SAMN05421553_2159 | SAMN05421553_2163 | Uncharacterized conserved protein, contains NRDE domain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.740 |
| SED17098.1 | SED17037.1 | SAMN05421553_2160 | SAMN05421553_2159 | Hypothetical protein. | Uncharacterized conserved protein, contains NRDE domain. | 0.875 |
| SED17098.1 | SED17146.1 | SAMN05421553_2160 | SAMN05421553_2161 | Hypothetical protein. | Hypothetical protein. | 0.646 |
| SED17098.1 | lgt | SAMN05421553_2160 | SAMN05421553_2162 | Hypothetical protein. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.625 |
| SED17098.1 | thyA | SAMN05421553_2160 | SAMN05421553_2163 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.647 |
| SED17146.1 | SED17037.1 | SAMN05421553_2161 | SAMN05421553_2159 | Hypothetical protein. | Uncharacterized conserved protein, contains NRDE domain. | 0.745 |
| SED17146.1 | SED17098.1 | SAMN05421553_2161 | SAMN05421553_2160 | Hypothetical protein. | Hypothetical protein. | 0.646 |
| SED17146.1 | SED17486.1 | SAMN05421553_2161 | SAMN05421553_2167 | Hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.475 |
| SED17146.1 | lgt | SAMN05421553_2161 | SAMN05421553_2162 | Hypothetical protein. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.885 |
| SED17146.1 | thyA | SAMN05421553_2161 | SAMN05421553_2163 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.868 |
| SED17486.1 | SED17037.1 | SAMN05421553_2167 | SAMN05421553_2159 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Uncharacterized conserved protein, contains NRDE domain. | 0.439 |
| SED17486.1 | SED17146.1 | SAMN05421553_2167 | SAMN05421553_2161 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.475 |
| SED17486.1 | lgt | SAMN05421553_2167 | SAMN05421553_2162 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.494 |
| SED17486.1 | thyA | SAMN05421553_2167 | SAMN05421553_2163 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| SED25187.1 | SED17037.1 | SAMN05421553_2318 | SAMN05421553_2159 | Glutamate synthase (NADPH) large subunit. | Uncharacterized conserved protein, contains NRDE domain. | 0.532 |
