| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEB94849.1 | SED17486.1 | SAMN05421553_0073 | SAMN05421553_2167 | Dihydromonapterin reductase / dihydrofolate reductase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.901 |
| SEB94849.1 | SED30499.1 | SAMN05421553_0073 | SAMN05421553_2420 | Dihydromonapterin reductase / dihydrofolate reductase. | Aminomethyltransferase. | 0.880 |
| SEB94849.1 | SED81224.1 | SAMN05421553_0073 | SAMN05421553_3388 | Dihydromonapterin reductase / dihydrofolate reductase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.872 |
| SEB94849.1 | SEE04909.1 | SAMN05421553_0073 | SAMN05421553_3920 | Dihydromonapterin reductase / dihydrofolate reductase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.879 |
| SEB94849.1 | glyA | SAMN05421553_0073 | SAMN05421553_0629 | Dihydromonapterin reductase / dihydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.874 |
| SEB94849.1 | glyA-2 | SAMN05421553_0073 | SAMN05421553_1775 | Dihydromonapterin reductase / dihydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.874 |
| SEB94849.1 | glyA-3 | SAMN05421553_0073 | SAMN05421553_2422 | Dihydromonapterin reductase / dihydrofolate reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.874 |
| SEB94849.1 | purH | SAMN05421553_0073 | SAMN05421553_0680 | Dihydromonapterin reductase / dihydrofolate reductase. | IMP cyclohydrolase. | 0.872 |
| SEB94849.1 | purN | SAMN05421553_0073 | SAMN05421553_3604 | Dihydromonapterin reductase / dihydrofolate reductase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.878 |
| SEB94849.1 | thyA | SAMN05421553_0073 | SAMN05421553_2163 | Dihydromonapterin reductase / dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.873 |
| SED17486.1 | SEB94849.1 | SAMN05421553_2167 | SAMN05421553_0073 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydromonapterin reductase / dihydrofolate reductase. | 0.901 |
| SED17486.1 | SED30499.1 | SAMN05421553_2167 | SAMN05421553_2420 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase. | 0.935 |
| SED17486.1 | SED81224.1 | SAMN05421553_2167 | SAMN05421553_3388 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.968 |
| SED17486.1 | SEE04909.1 | SAMN05421553_2167 | SAMN05421553_3920 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.905 |
| SED17486.1 | glyA | SAMN05421553_2167 | SAMN05421553_0629 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.888 |
| SED17486.1 | glyA-2 | SAMN05421553_2167 | SAMN05421553_1775 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.888 |
| SED17486.1 | glyA-3 | SAMN05421553_2167 | SAMN05421553_2422 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.888 |
| SED17486.1 | purH | SAMN05421553_2167 | SAMN05421553_0680 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | IMP cyclohydrolase. | 0.889 |
| SED17486.1 | purN | SAMN05421553_2167 | SAMN05421553_3604 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.885 |
| SED17486.1 | thyA | SAMN05421553_2167 | SAMN05421553_2163 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
