| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SED21921.1 | SED26728.1 | SAMN05421553_2255 | SAMN05421553_2348 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | O-acetylhomoserine sulfhydrylase. | 0.548 |
| SED21921.1 | SEE04909.1 | SAMN05421553_2255 | SAMN05421553_3920 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
| SED21921.1 | SEE74988.1 | SAMN05421553_2255 | SAMN05421553_4993 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Homoserine dehydrogenase. | 0.913 |
| SED21921.1 | ahcY | SAMN05421553_2255 | SAMN05421553_2256 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.894 |
| SED21921.1 | metE | SAMN05421553_2255 | SAMN05421553_3010 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.973 |
| SED21921.1 | metK | SAMN05421553_2255 | SAMN05421553_2273 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.906 |
| SED21921.1 | metZ | SAMN05421553_2255 | SAMN05421553_3392 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.926 |
| SED26728.1 | SED21921.1 | SAMN05421553_2348 | SAMN05421553_2255 | O-acetylhomoserine sulfhydrylase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.548 |
| SED26728.1 | SED87471.1 | SAMN05421553_2348 | SAMN05421553_3529 | O-acetylhomoserine sulfhydrylase. | Cysteine synthase A. | 0.887 |
| SED26728.1 | SEE04909.1 | SAMN05421553_2348 | SAMN05421553_3920 | O-acetylhomoserine sulfhydrylase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.981 |
| SED26728.1 | SEE26538.1 | SAMN05421553_2348 | SAMN05421553_4390 | O-acetylhomoserine sulfhydrylase. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.925 |
| SED26728.1 | SEE74988.1 | SAMN05421553_2348 | SAMN05421553_4993 | O-acetylhomoserine sulfhydrylase. | Homoserine dehydrogenase. | 0.948 |
| SED26728.1 | ahcY | SAMN05421553_2348 | SAMN05421553_2256 | O-acetylhomoserine sulfhydrylase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.886 |
| SED26728.1 | metE | SAMN05421553_2348 | SAMN05421553_3010 | O-acetylhomoserine sulfhydrylase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.954 |
| SED26728.1 | metK | SAMN05421553_2348 | SAMN05421553_2273 | O-acetylhomoserine sulfhydrylase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.896 |
| SED26728.1 | metZ | SAMN05421553_2348 | SAMN05421553_3392 | O-acetylhomoserine sulfhydrylase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.913 |
| SED87471.1 | SED26728.1 | SAMN05421553_3529 | SAMN05421553_2348 | Cysteine synthase A. | O-acetylhomoserine sulfhydrylase. | 0.887 |
| SED87471.1 | SEE04909.1 | SAMN05421553_3529 | SAMN05421553_3920 | Cysteine synthase A. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.914 |
| SED87471.1 | SEE26538.1 | SAMN05421553_3529 | SAMN05421553_4390 | Cysteine synthase A. | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.872 |
| SED87471.1 | SEE74988.1 | SAMN05421553_3529 | SAMN05421553_4993 | Cysteine synthase A. | Homoserine dehydrogenase. | 0.744 |
