STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGuroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (463 aa)    
Predicted Functional Partners:
cbiX
Sirohydrochlorin cobaltochelatase.
 
 
 0.997
cysH
Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.992
sir
Sulfite reductase (NADPH) hemoprotein beta-component.
 
  
 0.991
cysC
Adenylylsulfate kinase /sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
  
  
 0.988
cobI
Precorrin-2/cobalt-factor-2 C20-methyltransferase.
 
 
 0.981
SEP87353.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.969
cobA
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
0.963
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.961
nasE
Nitrite reductase (NADH) small subunit.
 
  
 0.960
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.945
Your Current Organism:
Thalassobius gelatinovorus
NCBI taxonomy Id: 53501
Other names: ATCC 25655, Agrobacterium gelatinovorum, CECT 4357, CIP 105976, DSM 5887, IAM 12617, JCM 20688, LMG 129, LMG:129, NBRC 15761, Ruegeria gelatinovora, Ruegeria gelatinovorans, T. gelatinovorus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.