LENED_002397 protein (Lentinula edodes) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

LENED_002397

CDC14-domain-containing protein. (649 aa)

Predicted Functional Partners:

LENED_003629

0.709

LENED_010920

0.684

LENED_011973

0.684

LENED_002814

0.604

LENED_003642

0.604

LENED_005267

0.604

LENED_005266

0.604

LENED_005678

0.604

LENED_007366

0.604

LENED_012480

0.604

Your Current Organism:

Lentinula edodes

NCBI taxonomy Id: 5353
Other names: L. edodes, Lentinus edodes, shiitake mushroom

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LENED_002397	LENED_002814	A0A1Q3E0R7	A0A1Q3E1X9	CDC14-domain-containing protein.	Polyketide synthase.	0.604
LENED_002397	LENED_003629	A0A1Q3E0R7	A0A1Q3E443	CDC14-domain-containing protein.	Delta 5 fatty acid desaturase.	0.709
LENED_002397	LENED_003642	A0A1Q3E0R7	A0A1Q3E444	CDC14-domain-containing protein.	Protein.	0.604
LENED_002397	LENED_005266	A0A1Q3E0R7	A0A1Q3E8Y3	CDC14-domain-containing protein.	Polyketide synthase.	0.604
LENED_002397	LENED_005267	A0A1Q3E0R7	A0A1Q3E8F8	CDC14-domain-containing protein.	Polyketide synthase.	0.604
LENED_002397	LENED_005678	A0A1Q3E0R7	A0A1Q3E9N4	CDC14-domain-containing protein.	Protein.	0.604
LENED_002397	LENED_007366	A0A1Q3E0R7	A0A1Q3EED5	CDC14-domain-containing protein.	Polyketide synthase.	0.604
LENED_002397	LENED_010920	A0A1Q3E0R7	A0A1Q3ENP1	CDC14-domain-containing protein.	Molybdopterin binding oxidoreductase.	0.684
LENED_002397	LENED_011973	A0A1Q3E0R7	A0A1Q3ERE9	CDC14-domain-containing protein.	Sulfite oxidase.	0.684
LENED_002397	LENED_012480	A0A1Q3E0R7	A0A1Q3ESP4	CDC14-domain-containing protein.	Uncharacterized protein.	0.604
LENED_002814	LENED_002397	A0A1Q3E1X9	A0A1Q3E0R7	Polyketide synthase.	CDC14-domain-containing protein.	0.604
LENED_003629	LENED_002397	A0A1Q3E443	A0A1Q3E0R7	Delta 5 fatty acid desaturase.	CDC14-domain-containing protein.	0.709
LENED_003629	LENED_010920	A0A1Q3E443	A0A1Q3ENP1	Delta 5 fatty acid desaturase.	Molybdopterin binding oxidoreductase.	0.933
LENED_003629	LENED_011973	A0A1Q3E443	A0A1Q3ERE9	Delta 5 fatty acid desaturase.	Sulfite oxidase.	0.933
LENED_003642	LENED_002397	A0A1Q3E444	A0A1Q3E0R7	Protein.	CDC14-domain-containing protein.	0.604
LENED_005266	LENED_002397	A0A1Q3E8Y3	A0A1Q3E0R7	Polyketide synthase.	CDC14-domain-containing protein.	0.604
LENED_005266	LENED_005267	A0A1Q3E8Y3	A0A1Q3E8F8	Polyketide synthase.	Polyketide synthase.	0.920
LENED_005267	LENED_002397	A0A1Q3E8F8	A0A1Q3E0R7	Polyketide synthase.	CDC14-domain-containing protein.	0.604
LENED_005267	LENED_005266	A0A1Q3E8F8	A0A1Q3E8Y3	Polyketide synthase.	Polyketide synthase.	0.920
LENED_005678	LENED_002397	A0A1Q3E9N4	A0A1Q3E0R7	Protein.	CDC14-domain-containing protein.	0.604

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.883

expected number of edges:

11

PPI enrichment p-value:

3.33e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006473

Protein acetylation

4 of 72

1.81

1.24

0.0031

GO:0017196

N-terminal peptidyl-methionine acetylation

2 of 5

2.67

0.78

0.0393

GO:0002031

G protein-coupled receptor internalization

2 of 5

2.67

0.78

0.0393

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 7

2.52

0.77

0.0393

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

4 of 109

1.63

1.12

0.0043

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031248

Protein acetyltransferase complex

5 of 54

2.03

2.84

9.75e-07

GO:0070461

SAGA-type complex

3 of 16

2.34

1.97

0.00019

GO:0031415

NatA complex

2 of 3

2.89

1.54

0.0016

GO:0140672

ATAC complex

2 of 6

2.59

1.36

0.0033

GO:0005834

Heterotrimeric G-protein complex

2 of 21

2.04

0.92

0.0188

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19863

N-terminal protein amino acid acetylation

3 of 7

2.7

2.1

0.00014

CL:5844

SAGA complex, and SWIRM domain

2 of 6

2.59

0.99

0.0156

CL:16972

Mixed, incl. Amine ligand-binding receptors, and Heterotrimeric G-protein complex

3 of 68

1.71

0.9

0.0163

CL:17078

Mixed, incl. G protein-coupled receptor kinase activity, and Arrestin

2 of 14

2.22

0.89

0.0222

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5635838

Activation of SMO

2 of 8

2.46

0.72

0.0484

MAP-418555

G alpha (s) signalling events

3 of 89

1.59

0.66

0.0484

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031248

Protein acetyltransferase complex

5 of 48

2.08

2.97

6.08e-07

GOCC:0070461

SAGA-type complex

3 of 14

2.4

2.05

0.00014

GOCC:0031415

NatA complex

2 of 4

2.76

1.46

0.0022

GOCC:0005834

Heterotrimeric G-protein complex

2 of 11

2.32

1.14

0.0077

GOCC:1902494

Catalytic complex

7 of 848

0.98

0.87

0.00050

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.52

0.81

0.0344

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR021183

N-terminal acetyltransferase A, auxiliary subunit

2 of 2

3.06

0.96

0.0187

IPR017864

Arrestin, conserved site

2 of 3

2.89

0.96

0.0187

IPR014753

Arrestin, N-terminal

2 of 3

2.89

0.96

0.0187

IPR000698

Arrestin

2 of 3

2.89

0.96

0.0187

IPR000367

G-protein alpha subunit, group S

2 of 2

3.06

0.96

0.0187

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01017

Arrestin (or S-antigen), C-terminal domain

2 of 7

2.52

1.0

0.0150

SM00275

G protein alpha subunit

2 of 15

2.19

0.84

0.0282

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