LENED_004018 protein (Lentinula edodes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

LENED_004018

Uncharacterized protein. (385 aa)

Predicted Functional Partners:

LENED_005241

0.771

LENED_012680

0.749

LENED_001982

0.716

LENED_004046

0.603

LENED_002520

0.560

LENED_001763

0.557

LENED_009497

0.555

LENED_009496

0.555

LENED_009370

0.551

LENED_009366

0.551

Your Current Organism:

Lentinula edodes

NCBI taxonomy Id: 5353
Other names: L. edodes, Lentinus edodes, shiitake mushroom

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LENED_001763	LENED_001982	A0A1Q3DZC7	A0A1Q3DZX9	Ras-domain-containing protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.613
LENED_001763	LENED_002520	A0A1Q3DZC7	A0A1Q3E125	Ras-domain-containing protein.	Nonmuscle myosin heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.523
LENED_001763	LENED_004018	A0A1Q3DZC7	A0A1Q3E5E2	Ras-domain-containing protein.	Uncharacterized protein.	0.557
LENED_001763	LENED_004046	A0A1Q3DZC7	A0A1Q3E578	Ras-domain-containing protein.	Microtubule associated protein.	0.626
LENED_001763	LENED_005241	A0A1Q3DZC7	A0A1Q3E8H0	Ras-domain-containing protein.	Serine/threonine-protein kinase.	0.773
LENED_001763	LENED_012680	A0A1Q3DZC7	A0A1Q3ET99	Ras-domain-containing protein.	Serine threonine-protein kinase PLK4.	0.731
LENED_001982	LENED_001763	A0A1Q3DZX9	A0A1Q3DZC7	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Ras-domain-containing protein.	0.613
LENED_001982	LENED_004018	A0A1Q3DZX9	A0A1Q3E5E2	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.716
LENED_001982	LENED_005241	A0A1Q3DZX9	A0A1Q3E8H0	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Serine/threonine-protein kinase.	0.954
LENED_001982	LENED_009366	A0A1Q3DZX9	A0A1Q3EJN9	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	G2 mitotic-specific cyclin cdc13; Belongs to the cyclin family.	0.832
LENED_001982	LENED_009370	A0A1Q3DZX9	A0A1Q3EJK3	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	G2 mitotic-specific cyclin cdc13; Belongs to the cyclin family.	0.832
LENED_001982	LENED_009496	A0A1Q3DZX9	A0A1Q3EK06	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Cysteine-type endopeptidase.	0.928
LENED_001982	LENED_009497	A0A1Q3DZX9	A0A1Q3EJW7	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Cysteine-type endopeptidase.	0.928
LENED_001982	LENED_012680	A0A1Q3DZX9	A0A1Q3ET99	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Serine threonine-protein kinase PLK4.	0.926
LENED_002520	LENED_001763	A0A1Q3E125	A0A1Q3DZC7	Nonmuscle myosin heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Ras-domain-containing protein.	0.523
LENED_002520	LENED_004018	A0A1Q3E125	A0A1Q3E5E2	Nonmuscle myosin heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.560
LENED_002520	LENED_005241	A0A1Q3E125	A0A1Q3E8H0	Nonmuscle myosin heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Serine/threonine-protein kinase.	0.605
LENED_004018	LENED_001763	A0A1Q3E5E2	A0A1Q3DZC7	Uncharacterized protein.	Ras-domain-containing protein.	0.557
LENED_004018	LENED_001982	A0A1Q3E5E2	A0A1Q3DZX9	Uncharacterized protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.716
LENED_004018	LENED_002520	A0A1Q3E5E2	A0A1Q3E125	Uncharacterized protein.	Nonmuscle myosin heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.560

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.949

expected number of edges:

10

PPI enrichment p-value:

6.12e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098930

Axonal transport

5 of 32

2.37

3.67

5.68e-08

GO:0047497

Mitochondrion transport along microtubule

4 of 12

2.7

3.6

1.89e-07

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.58

3.41

3.47e-07

GO:0010970

Transport along microtubule

6 of 110

1.92

3.05

1.03e-07

GO:0000413

Protein peptidyl-prolyl isomerization

4 of 29

2.32

2.87

2.53e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.67

3.31

6.55e-07

GO:0008574

Plus-end-directed microtubule motor activity

2 of 11

2.44

1.02

0.0137

GO:0031267

Small GTPase binding

4 of 230

1.42

0.89

0.0104

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

4 of 6

3.0

4.11

2.87e-08

GO:0005642

Annulate lamellae

4 of 7

2.94

4.09

2.87e-08

GO:0106068

SUMO ligase complex

4 of 11

2.74

3.97

3.74e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.74

3.97

3.74e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.67

3.89

4.65e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15666

Establishment of mitochondrion localization, and CH-like domain in sperm protein

3 of 11

2.61

1.92

0.00029

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

3 of 29

2.19

1.58

0.00098

CL:16207

RHO GTPases activate KTN1

2 of 5

2.78

1.33

0.0039

CL:15669

MIRO domain, and HAP1, N-terminal

2 of 5

2.78

1.33

0.0039

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.64

1.25

0.0052

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.17

2.56

7.94e-06

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.18

2.56

7.94e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.17

2.56

7.94e-06

MAP-159234

Transport of Mature mRNAs Derived from Intronless Transcripts

4 of 44

2.14

2.54

7.94e-06

MAP-159230

Transport of the SLBP Dependant Mature mRNA

4 of 43

2.15

2.54

7.94e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.08

4.21

2.01e-08

GOCC:0031967

Organelle envelope

6 of 427

1.33

1.42

6.42e-05

GOCC:0043229

Intracellular organelle

11 of 6905

0.38

0.29

0.0165

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

2 of 8

2.58

1.04

0.0130

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