STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LENED_007194Ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (178 aa)    
Predicted Functional Partners:
LENED_000880
Ubiquitin activating enzyme.
    
 0.938
LENED_011333
Ubiquitin-conjugating enzyme e2 w-like.
   
 0.829
LENED_009925
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]
    
 0.818
LENED_006245
UBC-like protein.
     
 0.814
LENED_007143
Ubiquitin conjugating enzyme family protein.
   
 0.814
LENED_002763
NEDD8 activating enzyme.
    
 0.808
LENED_002761
NEDD8 activating enzyme.
    
 0.808
LENED_002762
Nedd8 activating enzyme.
    
 0.808
LENED_008348
UBC-like protein.
     
 0.798
LENED_011417
Ubiquitin-conjugating enzyme e2-24 kDa; Belongs to the ubiquitin-conjugating enzyme family.
   
0.788
Your Current Organism:
Lentinula edodes
NCBI taxonomy Id: 5353
Other names: L. edodes, Lentinus edodes, shiitake mushroom
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.