FEN1 protein (Lentinula edodes) - STRING interaction network

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FEN1

Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (438 aa)

Predicted Functional Partners:

LENED_006534

0.990

LENED_011755

0.984

LENED_007417

0.983

LENED_011676

0.983

LENED_005340

0.978

LENED_006087

0.978

LENED_003555

0.972

LENED_000148

0.971

LENED_001416

0.960

LENED_007181

0.958

Your Current Organism:

Lentinula edodes

NCBI taxonomy Id: 5353
Other names: L. edodes, Lentinus edodes, shiitake mushroom

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	LENED_000148	A0A1Q3ERF1	A0A1Q3DVF6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication ATP-dependent helicase Dna2.	0.971
FEN1	LENED_001416	A0A1Q3ERF1	A0A1Q3DYC7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Dna repair protein rad50.	0.960
FEN1	LENED_003555	A0A1Q3ERF1	A0A1Q3E3X3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase subunit delta-2.	0.972
FEN1	LENED_005340	A0A1Q3ERF1	A0A1Q3E8N8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.978
FEN1	LENED_006087	A0A1Q3ERF1	A0A1Q3EAQ3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA ligase.	0.978
FEN1	LENED_006534	A0A1Q3ERF1	A0A1Q3EBX0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease H-like protein.	0.990
FEN1	LENED_007181	A0A1Q3ERF1	A0A1Q3EDP0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Aaa family protein.	0.958
FEN1	LENED_007417	A0A1Q3ERF1	A0A1Q3EEI4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase delta catalytic variant.	0.983
FEN1	LENED_011676	A0A1Q3ERF1	A0A1Q3EQN0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase; Belongs to the actin family.	0.983
FEN1	LENED_011755	A0A1Q3ERF1	A0A1Q3EQW3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.984
LENED_000148	FEN1	A0A1Q3DVF6	A0A1Q3ERF1	DNA replication ATP-dependent helicase Dna2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.971
LENED_000148	LENED_001416	A0A1Q3DVF6	A0A1Q3DYC7	DNA replication ATP-dependent helicase Dna2.	Dna repair protein rad50.	0.757
LENED_000148	LENED_003555	A0A1Q3DVF6	A0A1Q3E3X3	DNA replication ATP-dependent helicase Dna2.	DNA polymerase subunit delta-2.	0.800
LENED_000148	LENED_005340	A0A1Q3DVF6	A0A1Q3E8N8	DNA replication ATP-dependent helicase Dna2.	DNA ligase.	0.561
LENED_000148	LENED_006087	A0A1Q3DVF6	A0A1Q3EAQ3	DNA replication ATP-dependent helicase Dna2.	DNA ligase.	0.561
LENED_000148	LENED_006534	A0A1Q3DVF6	A0A1Q3EBX0	DNA replication ATP-dependent helicase Dna2.	Ribonuclease H-like protein.	0.988
LENED_000148	LENED_007181	A0A1Q3DVF6	A0A1Q3EDP0	DNA replication ATP-dependent helicase Dna2.	Aaa family protein.	0.917
LENED_000148	LENED_007417	A0A1Q3DVF6	A0A1Q3EEI4	DNA replication ATP-dependent helicase Dna2.	DNA polymerase delta catalytic variant.	0.855
LENED_000148	LENED_011676	A0A1Q3DVF6	A0A1Q3EQN0	DNA replication ATP-dependent helicase Dna2.	DNA polymerase; Belongs to the actin family.	0.867
LENED_000148	LENED_011755	A0A1Q3DVF6	A0A1Q3EQW3	DNA replication ATP-dependent helicase Dna2.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.922

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