STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Coexpression
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[Homology]
Score
glnDUTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (933 aa)    
Predicted Functional Partners:
AEH89003.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002187:IPR002332:IPR017918; KEGG: mlo:mll0345 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.983
AEH85553.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002187:IPR002332:IPR017918; KEGG: mlo:mll4247 GlnK, nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.841
glnE
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
 
   
 0.815
murJ
Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
     
 0.657
AEH86405.1
COGs: COG0069 Glutamate synthase domain 2; InterProIPR017932:IPR000583:IPR006982:IPR002932:IPR 002489; KEGG: mlo:mll3030 glutamate synthase, large subunit; PFAM: glutamine amidotransferase class-II; glutamate synthase; ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.598
AEH88957.1
COGs: COG3852 Signal transduction histidine kinase nitrogen specific; InterProIPR013767:IPR003661:IPR003594:IPR005467:IPR 004358; KEGG: mlo:mlr0397 nitrogen reguration protein NirB protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold.
  
 
 
 0.583
AEH85554.1
Ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR017909:IPR001905:IPR018047; KEGG: mlo:mll4246 ammonium transporter AmtB; PFAM: ammonium transporter; SPTR: Ammonium transporter; TIGRFAM: ammonium transporter; PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter.
 
   
 0.543
AEH84684.1
COGs: COG3306 Glycosyltransferase involved in LPS biosynthesis; InterPro IPR002654; KEGG: mlo:mll5323 glycosyl transferase; PFAM: glycosyl transferase family 25; SPTR: Glycosyl transferase family 25; PFAM: Glycosyltransferase family 25 (LPS biosynthesis protein).
       0.541
bamA
Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.504
cobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
   
    0.489
Your Current Organism:
Mesorhizobium opportunistum
NCBI taxonomy Id: 536019
Other names: M. opportunistum WSM2075, Mesorhizobium opportunistum WSM2075, Mesorhizobium opportunistum str. WSM2075, Mesorhizobium opportunistum strain WSM2075, Mesorhizobium sp. LMG 24607, Mesorhizobium sp. WSM2075
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