node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEH88674.1 | AEH90979.1 | Mesop_4242 | Mesop_6658 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | 0.915 |
AEH88674.1 | clpP-2 | Mesop_4242 | Mesop_4871 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.864 |
AEH88674.1 | dnaK | Mesop_4242 | Mesop_0739 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.953 |
AEH88674.1 | grpE | Mesop_4242 | Mesop_1783 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.871 |
AEH88674.1 | hrcA | Mesop_4242 | Mesop_0801 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.693 |
AEH88674.1 | lon | Mesop_4242 | Mesop_4869 | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.770 |
AEH90979.1 | AEH88674.1 | Mesop_6658 | Mesop_4242 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | ATP-dependent Clp protease, ATP-binding subunit clpA; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR013461:IPR004176:IPR003959:IPR013093:IPR 019489:IPR001270:IPR003593:IPR018368; KEGG: mlo:mll0663 endopeptidase Clp ATP-binding chain A; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATP-dependent Clp protease, ATP-binding subunit clpA; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB pro [...] | 0.915 |
AEH90979.1 | clpB | Mesop_6658 | Mesop_1664 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.915 |
AEH90979.1 | clpP-2 | Mesop_6658 | Mesop_4871 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.685 |
AEH90979.1 | grpE | Mesop_6658 | Mesop_1783 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.979 |
AEH90979.1 | hrcA | Mesop_6658 | Mesop_0801 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.873 |
AEH90979.1 | lon | Mesop_6658 | Mesop_4869 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.715 |
AEH90979.1 | rplK | Mesop_6658 | Mesop_4635 | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.627 |
clpB | AEH90979.1 | Mesop_1664 | Mesop_6658 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | COGs: COG0443 Molecular chaperone; InterPro IPR018181:IPR001023; KEGG: mlo:mll5617 DnaK-type molecular chaperone DnaK; SPTR: DnaK-type molecular chaperone DnaK; PFAM: Hsp70 protein. | 0.915 |
clpB | clpP-2 | Mesop_1664 | Mesop_4871 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.868 |
clpB | clpX | Mesop_1664 | Mesop_4870 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.434 |
clpB | dnaK | Mesop_1664 | Mesop_0739 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.954 |
clpB | grpE | Mesop_1664 | Mesop_1783 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.883 |
clpB | hrcA | Mesop_1664 | Mesop_0801 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.693 |
clpB | lon | Mesop_1664 | Mesop_4869 | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.770 |