STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queE7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (244 aa)    
Predicted Functional Partners:
AEH90542.1
COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: rhi:NGR_b18170 6-pyruvoyl tetrahydrobiopterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein.
 
 
 0.999
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.999
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.963
folE
COGs: COG0302 GTP cyclohydrolase I; InterPro IPR001474:IPR020602:IPR018234; KEGG: mlo:mlr0922 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
  
  
 0.606
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.559
rlmH
Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
   
    0.485
cysN
Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
     
 0.461
cysN-2
Sulfate adenylyltransferase, large subunit; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
     
 0.461
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
     
 0.451
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
  
 0.451
Your Current Organism:
Mesorhizobium opportunistum
NCBI taxonomy Id: 536019
Other names: M. opportunistum WSM2075, Mesorhizobium opportunistum WSM2075, Mesorhizobium opportunistum str. WSM2075, Mesorhizobium opportunistum strain WSM2075, Mesorhizobium sp. LMG 24607, Mesorhizobium sp. WSM2075
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