A0A5C3MX85 protein (Heliocybe sulcata) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

A0A5C3MX85

RCC1/BLIP-II. (525 aa)

Predicted Functional Partners:

A0A5C3NB23

0.924

A0A5C3NBB9

0.908

A0A5C3NCZ2

0.788

A0A5C3NLL4

0.788

A0A5C3NH57

0.740

A0A5C3MXL2

0.718

A0A5C3MZI2

0.701

A0A5C3N1Z5

0.701

A0A5C3NKM7

0.667

A0A5C3N8H0

0.664

Your Current Organism:

Heliocybe sulcata

NCBI taxonomy Id: 5364
Other names: H. sulcata, Lentinus sulcatus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A5C3MX85	A0A5C3MXL2	RCC1/BLIP-II.	Serine/threonine-protein kinase.	0.718
A0A5C3MX85	A0A5C3MZI2	RCC1/BLIP-II.	WD40 repeat-like protein.	0.701
A0A5C3MX85	A0A5C3N1Z5	RCC1/BLIP-II.	WD40 repeat-like protein.	0.701
A0A5C3MX85	A0A5C3N8H0	RCC1/BLIP-II.	LAG1-DNAbind-domain-containing protein.	0.664
A0A5C3MX85	A0A5C3NB23	RCC1/BLIP-II.	RanBD1 domain-containing protein.	0.924
A0A5C3MX85	A0A5C3NBB9	RCC1/BLIP-II.	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.908
A0A5C3MX85	A0A5C3NCZ2	RCC1/BLIP-II.	GTP-binding protein ypt1.	0.788
A0A5C3MX85	A0A5C3NH57	RCC1/BLIP-II.	CS-domain-containing protein.	0.740
A0A5C3MX85	A0A5C3NKM7	RCC1/BLIP-II.	Spindle assembly checkpoint protein.	0.667
A0A5C3MX85	A0A5C3NLL4	RCC1/BLIP-II.	Importin subunit alpha; Belongs to the importin alpha family.	0.788
A0A5C3MXL2	A0A5C3MX85	Serine/threonine-protein kinase.	RCC1/BLIP-II.	0.718
A0A5C3MXL2	A0A5C3MZI2	Serine/threonine-protein kinase.	WD40 repeat-like protein.	0.992
A0A5C3MXL2	A0A5C3N1Z5	Serine/threonine-protein kinase.	WD40 repeat-like protein.	0.977
A0A5C3MXL2	A0A5C3NB23	Serine/threonine-protein kinase.	RanBD1 domain-containing protein.	0.635
A0A5C3MXL2	A0A5C3NCZ2	Serine/threonine-protein kinase.	GTP-binding protein ypt1.	0.707
A0A5C3MXL2	A0A5C3NH57	Serine/threonine-protein kinase.	CS-domain-containing protein.	0.984
A0A5C3MXL2	A0A5C3NKM7	Serine/threonine-protein kinase.	Spindle assembly checkpoint protein.	0.957
A0A5C3MXL2	A0A5C3NLL4	Serine/threonine-protein kinase.	Importin subunit alpha; Belongs to the importin alpha family.	0.492
A0A5C3MZI2	A0A5C3MX85	WD40 repeat-like protein.	RCC1/BLIP-II.	0.701
A0A5C3MZI2	A0A5C3MXL2	WD40 repeat-like protein.	Serine/threonine-protein kinase.	0.992

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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