node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A5C3MKR3 | A0A5C3N2F0 | A0A5C3MKR3 | A0A5C3N2F0 | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | Uncharacterized protein. | 0.975 |
A0A5C3MKR3 | A0A5C3N9V4 | A0A5C3MKR3 | A0A5C3N9V4 | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.970 |
A0A5C3MKR3 | KAE1 | A0A5C3MKR3 | A0A5C3NTT0 | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.996 |
A0A5C3MZQ7 | A0A5C3N2F0 | A0A5C3MZQ7 | A0A5C3N2F0 | Glutaredoxin. | Uncharacterized protein. | 0.446 |
A0A5C3N2F0 | A0A5C3MKR3 | A0A5C3N2F0 | A0A5C3MKR3 | Uncharacterized protein. | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | 0.975 |
A0A5C3N2F0 | A0A5C3MZQ7 | A0A5C3N2F0 | A0A5C3MZQ7 | Uncharacterized protein. | Glutaredoxin. | 0.446 |
A0A5C3N2F0 | A0A5C3N4P1 | A0A5C3N2F0 | A0A5C3N4P1 | Uncharacterized protein. | Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. | 0.446 |
A0A5C3N2F0 | A0A5C3N9V4 | A0A5C3N2F0 | A0A5C3N9V4 | Uncharacterized protein. | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.935 |
A0A5C3N2F0 | KAE1 | A0A5C3N2F0 | A0A5C3NTT0 | Uncharacterized protein. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.968 |
A0A5C3N2F0 | TRM8 | A0A5C3N2F0 | A0A5C3MYH2 | Uncharacterized protein. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.527 |
A0A5C3N2F0 | TRM82 | A0A5C3N2F0 | A0A5C3N5V0 | Uncharacterized protein. | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. | 0.412 |
A0A5C3N4P1 | A0A5C3N2F0 | A0A5C3N4P1 | A0A5C3N2F0 | Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. | Uncharacterized protein. | 0.446 |
A0A5C3N9V4 | A0A5C3MKR3 | A0A5C3N9V4 | A0A5C3MKR3 | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | 0.970 |
A0A5C3N9V4 | A0A5C3N2F0 | A0A5C3N9V4 | A0A5C3N2F0 | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | Uncharacterized protein. | 0.935 |
A0A5C3N9V4 | KAE1 | A0A5C3N9V4 | A0A5C3NTT0 | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | 0.532 |
KAE1 | A0A5C3MKR3 | A0A5C3NTT0 | A0A5C3MKR3 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | CGI-121-domain-containing protein; Belongs to the CGI121/TPRKB family. | 0.996 |
KAE1 | A0A5C3N2F0 | A0A5C3NTT0 | A0A5C3N2F0 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | Uncharacterized protein. | 0.968 |
KAE1 | A0A5C3N9V4 | A0A5C3NTT0 | A0A5C3N9V4 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. | 0.532 |
TRM8 | A0A5C3N2F0 | A0A5C3MYH2 | A0A5C3N2F0 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | Uncharacterized protein. | 0.527 |
TRM8 | TRM82 | A0A5C3MYH2 | A0A5C3N5V0 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. | 0.999 |