STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folC-2KEGG: cpf:CPF_2174 5.0e-66 folC; FolC bifunctional protein K01927:K01930; Psort location: Cytoplasmic, score: 8.87; Belongs to the folylpolyglutamate synthase family. (433 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.989
folC
Bifunctional protein FolC; KEGG: tte:TTE0783 3.0e-84 folC; Folylpolyglutamate synthase K01930; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.920
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.913
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.864
thyA
Thymidylate synthase; KEGG: bsu:BG11190 9.1e-51 thyA; thymidylate synthase A K00560; Psort location: Cytoplasmic, score: 9.98.
     
 0.827
EEX20948.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
 
     0.813
EEX20947.1
Tetratricopeptide repeat protein; Psort location: Cytoplasmic, score: 8.87.
       0.779
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
       0.657
EEX20943.1
Putative RNA polymerase sigma-F factor; KEGG: reh:H16_A2725 4.5e-22 rpoD1; DNA-directed RNA polymerase sigma subunit (RpoD) K00960; Psort location: Cytoplasmic, score: 9.98; Belongs to the sigma-70 factor family.
       0.639
EEX20946.1
Hypothetical protein.
       0.639
Your Current Organism:
Blautia hansenii
NCBI taxonomy Id: 537007
Other names: B. hansenii DSM 20583, Blautia hansenii DSM 20583, Blautia hansenii str. DSM 20583, Blautia hansenii strain DSM 20583, Ruminococcus hansenii DSM 20583
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.