STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)    
Predicted Functional Partners:
pgi
KEGG: bfr:BF3812 1.0e-186 glucose-6-phosphate isomerase K01810; Psort location: Cytoplasmic, score: 9.26; Belongs to the GPI family.
  
 0.981
fba
KEGG: bth:BT1691 1.5e-135 fructose-bisphosphate aldolase, class II K01624.
 
 
 0.957
fbp
KEGG: bth:BT1228 4.7e-237 fructose-1,6-bisphosphatase K04041; Psort location: Cytoplasmic, score: 8.96.
     
 0.940
EFB36368.1
Transketolase, thiamine diphosphate binding domain protein; KEGG: bth:BT0347 2.2e-285 transketolase K00615; Belongs to the transketolase family.
  
 
 0.891
pfp
Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
  
 
0.880
EFB34276.1
Kinase, PfkB family; KEGG: bfr:BF0171 2.8e-88 fructokinase K00847.
   
 
 0.874
EFB34083.1
Kinase, PfkB family; KEGG: bth:BT1757 3.5e-106 fructokinase K00847; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.874
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
   
  
 0.794
pyk
Pyruvate kinase; KEGG: bfr:BF4482 3.8e-148 pyruvate kinase K00873; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.779
tpiA
Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
  
 0.672
Your Current Organism:
Prevotella copri
NCBI taxonomy Id: 537011
Other names: P. copri DSM 18205, Prevotella copri CB7, Prevotella copri DSM 18205, Prevotella copri JCM 13464, Prevotella copri str. DSM 18205, Prevotella copri strain DSM 18205
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