STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rdgBNon-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (215 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
 
 0.947
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.929
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
 
  0.919
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
   
 0.889
hpt
KEGG: bfr:BF1119 8.8e-53 putative hypoxanthine guanine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.26; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 
 0.878
EFB34378.1
Ser/Thr phosphatase family protein; KEGG: rsp:RSP_0955 1.5e-29 5'-nucleotidase K01081; Psort location: Periplasmic, score: 9.44.
   
 
  0.873
EFB34951.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.
 
    0.816
EFB34953.1
Glycosyltransferase, group 2 family protein; KEGG: chu:CHU_2532 4.2e-30 b-glycosyltransferase-related protein, glycosyltransferase family 2 protein K00754; Psort location: Cytoplasmic, score: 8.96.
       0.788
EFB34954.1
Two component regulator propeller.
       0.784
EFB34478.1
Phosphodiesterase family protein; KEGG: eci:UTI89_C2584 7.7e-38 yfcE; hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.711
Your Current Organism:
Prevotella copri
NCBI taxonomy Id: 537011
Other names: P. copri DSM 18205, Prevotella copri CB7, Prevotella copri DSM 18205, Prevotella copri JCM 13464, Prevotella copri str. DSM 18205, Prevotella copri strain DSM 18205
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