STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutLDNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa)    
Predicted Functional Partners:
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
 
 0.995
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.991
EFB34788.1
MutS domain V protein; KEGG: btk:BT9727_3510 1.2e-09 mutS; DNA mismatch repair protein K03555; Psort location: CytoplasmicMembrane, score: 9.16.
 
 0.989
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.979
recQ-2
KEGG: bfr:BF4076 2.6e-291 recQ; ATP-dependent DNA helicase RecQ K03654; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.840
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.787
EFB34929.1
PPIC-type PPIASE domain protein; KEGG: bth:BT3848 2.0e-140 peptidyl-prolyl cis-trans isomerase K03771.
 
 
   0.781
EFB34930.1
PPIC-type PPIASE domain protein; KEGG: chu:CHU_0192 2.1e-22 possible peptidyl-prolyl cis-trans isomerase K01802.
 
 
   0.761
EFB34928.1
Hypothetical protein.
       0.734
EFB36309.1
UvrD/REP helicase; KEGG: bfs:BF2555 4.4e-225 putative helicase K03657.
   
 
 0.725
Your Current Organism:
Prevotella copri
NCBI taxonomy Id: 537011
Other names: P. copri DSM 18205, Prevotella copri CB7, Prevotella copri DSM 18205, Prevotella copri JCM 13464, Prevotella copri str. DSM 18205, Prevotella copri strain DSM 18205
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