STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFB34825.1DNA gyrase/topoisomerase IV, A subunit; KEGG: bth:BT3579 0. topoisomerase IV subunit A K01864. (953 aa)    
Predicted Functional Partners:
EFB34254.1
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: pgi:PG0368 1.7e-214 DNA topoisomerase IV, B subunit, putative K02622; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.924
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.790
glyS
glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.669
EFB34823.1
KEGG: hch:HCH_00278 2.1e-12 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerases 1 K03773.
       0.642
EFB35700.1
Hypothetical protein.
   
   0.617
secD
Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.559
argS
arginine--tRNA ligase; KEGG: bfr:BF4421 1.3e-239 arginyl-tRNA synthetase K01887; Psort location: Cytoplasmic, score: 9.26.
  
  
 0.525
EFB35135.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.
  
    0.460
EFB34945.1
Putative ACR, COG1399; Psort location: Cytoplasmic, score: 8.96.
  
    0.455
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.449
Your Current Organism:
Prevotella copri
NCBI taxonomy Id: 537011
Other names: P. copri DSM 18205, Prevotella copri CB7, Prevotella copri DSM 18205, Prevotella copri JCM 13464, Prevotella copri str. DSM 18205, Prevotella copri strain DSM 18205
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