STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (927 aa)    
Predicted Functional Partners:
EFB35494.1
KEGG: bfs:BF3908 7.2e-106 putative 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.998
EFB36114.1
Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: mca:MCA1545 3.8e-49 metH; 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.96.
 
 0.997
EFB34481.1
KEGG: bth:BT2403 1.8e-299 homoserine dehydrogenase.
  
 
 0.978
fhs
KEGG: bfs:BF2256 1.6e-211 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.937
ilvA
KEGG: tma:TM0356 4.4e-106 threonine dehydratase catabolic K01754; Psort location: Cytoplasmic, score: 8.96.
  
 0.935
nifJ
Pyruvate synthase; KEGG: bfs:BF3168 0. nifJ; putative pyruvate-flavodoxin oxidoreductase K03737; Psort location: Cytoplasmic, score: 8.96.
    
 0.929
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.920
luxS
S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.919
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.910
rnfB
Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
    
 0.907
Your Current Organism:
Prevotella copri
NCBI taxonomy Id: 537011
Other names: P. copri DSM 18205, Prevotella copri CB7, Prevotella copri DSM 18205, Prevotella copri JCM 13464, Prevotella copri str. DSM 18205, Prevotella copri strain DSM 18205
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