| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEG29669.1 | EEG32116.1 | CLOSTMETH_02682 | CLOSTMETH_00267 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | AICARFT/IMPCHase bienzyme; KEGG: xtr:448061 1.7e-122 atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.87. | 0.999 |
| EEG29669.1 | fhs | CLOSTMETH_02682 | CLOSTMETH_00517 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | KEGG: chy:CHY_2385 5.2e-206 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.87. | 0.907 |
| EEG29669.1 | fmt | CLOSTMETH_02682 | CLOSTMETH_02647 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.880 |
| EEG29669.1 | folD | CLOSTMETH_02682 | CLOSTMETH_02823 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.877 |
| EEG29669.1 | glyA | CLOSTMETH_02682 | CLOSTMETH_03248 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
| EEG29669.1 | purN | CLOSTMETH_02682 | CLOSTMETH_00269 | KEGG: blo:BL1108 0. purL; phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 8.87. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| EEG30116.1 | fhs | CLOSTMETH_02277 | CLOSTMETH_00517 | KEGG: bha:BH1417 2.4e-27 5-formyltetrahydrofolate cyclo-ligase K01934; Psort location: Cytoplasmic, score: 8.87. | KEGG: chy:CHY_2385 5.2e-206 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.87. | 0.579 |
| EEG30116.1 | fmt | CLOSTMETH_02277 | CLOSTMETH_02647 | KEGG: bha:BH1417 2.4e-27 5-formyltetrahydrofolate cyclo-ligase K01934; Psort location: Cytoplasmic, score: 8.87. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.626 |
| EEG30116.1 | folD | CLOSTMETH_02277 | CLOSTMETH_02823 | KEGG: bha:BH1417 2.4e-27 5-formyltetrahydrofolate cyclo-ligase K01934; Psort location: Cytoplasmic, score: 8.87. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.900 |
| EEG30116.1 | purN | CLOSTMETH_02277 | CLOSTMETH_00269 | KEGG: bha:BH1417 2.4e-27 5-formyltetrahydrofolate cyclo-ligase K01934; Psort location: Cytoplasmic, score: 8.87. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.770 |
| EEG30801.1 | EEG30803.1 | CLOSTMETH_01556 | CLOSTMETH_01558 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | KEGG: ctc:CTC01806 9.6e-230 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.87. | 0.999 |
| EEG30801.1 | EEG32116.1 | CLOSTMETH_01556 | CLOSTMETH_00267 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | AICARFT/IMPCHase bienzyme; KEGG: xtr:448061 1.7e-122 atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.87. | 0.649 |
| EEG30801.1 | fhs | CLOSTMETH_01556 | CLOSTMETH_00517 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | KEGG: chy:CHY_2385 5.2e-206 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.87. | 0.777 |
| EEG30801.1 | folD | CLOSTMETH_01556 | CLOSTMETH_02823 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.868 |
| EEG30801.1 | glyA | CLOSTMETH_01556 | CLOSTMETH_03248 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
| EEG30801.1 | purN | CLOSTMETH_01556 | CLOSTMETH_00269 | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.694 |
| EEG30803.1 | EEG30801.1 | CLOSTMETH_01558 | CLOSTMETH_01556 | KEGG: ctc:CTC01806 9.6e-230 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.87. | KEGG: cjr:CJE1336 9.2e-58 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.87. | 0.999 |
| EEG30803.1 | EEG32116.1 | CLOSTMETH_01558 | CLOSTMETH_00267 | KEGG: ctc:CTC01806 9.6e-230 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.87. | AICARFT/IMPCHase bienzyme; KEGG: xtr:448061 1.7e-122 atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase K00602:K01492; Psort location: Cytoplasmic, score: 8.87. | 0.775 |
| EEG30803.1 | fhs | CLOSTMETH_01558 | CLOSTMETH_00517 | KEGG: ctc:CTC01806 9.6e-230 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.87. | KEGG: chy:CHY_2385 5.2e-206 fhs; formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 8.87. | 0.908 |
| EEG30803.1 | fmt | CLOSTMETH_01558 | CLOSTMETH_02647 | KEGG: ctc:CTC01806 9.6e-230 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; Psort location: Cytoplasmic, score: 8.87. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.777 |
