STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HCAN_0790Hypothetical protein containing a COG0037 MesJ predicted ATPase of the PP-loop superfamily implicated in cell cycle control domain; Belongs to the TtcA family. (257 aa)    
Predicted Functional Partners:
nifS
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
 
     0.919
HCAN_0979
Putative thiamine biosynthesis protein containing a COG2104 ThiS sulfur transfer domain.
  
   0.868
HCAN_0789
Multidrug-efflux transporter [Campylobacter lari RM2100].
       0.810
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.804
HCAN_0788
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.731
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
  0.693
siaA
UDP-N-acetylglucosamine 2-epimerase [Flavobacterium johnsoniae UW101].
  
 
 0.535
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
    0.531
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
    0.497
metS
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.493
Your Current Organism:
Helicobacter canadensis
NCBI taxonomy Id: 537970
Other names: H. canadensis MIT 98-5491, Helicobacter canadensis ATCC 700968, Helicobacter canadensis H438, Helicobacter canadensis MIT 98-5491, Helicobacter canadensis NCTC 13241, Helicobacter canadensis NLEP-16143, Helicobacter canadensis str. MIT 98-5491, Helicobacter canadensis strain MIT 98-5491
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