node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fgs_1 | fhs_3 | HMPREF3229_00132 | HMPREF3229_01860 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | 0.629 |
fgs_1 | folA | HMPREF3229_00132 | HMPREF3229_00317 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | KEGG: pce:PECL_916 1.1e-21 dfrA; dihydrofolate reductase; K00287 dihydrofolate reductase; Psort location: Cytoplasmic, score: 7.50. | 0.569 |
fgs_1 | folD | HMPREF3229_00132 | HMPREF3229_01526 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.592 |
fgs_1 | folE | HMPREF3229_00132 | HMPREF3229_00740 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | GTP cyclohydrolase I; KEGG: sne:SPN23F_02800 4.0e-70 folE; GTP cyclohydrolase I K01495; Psort location: Cytoplasmic, score: 7.50. | 0.491 |
fgs_1 | guaA | HMPREF3229_00132 | HMPREF3229_00210 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.563 |
fgs_1 | pabB | HMPREF3229_00132 | HMPREF3229_01211 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | KEGG: ava:Ava_3468 3.2e-148 anthranilate synthase, component II K13950; Psort location: Cytoplasmic, score: 9.97. | 0.492 |
fgs_1 | sulA | HMPREF3229_00132 | HMPREF3229_00645 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.984 |
fgs_1 | sulD | HMPREF3229_00132 | HMPREF3229_00742 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.929 |
fgs_1 | valS | HMPREF3229_00132 | HMPREF3229_00133 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. | 0.887 |
fgs_1 | ydiB | HMPREF3229_00132 | HMPREF3229_00798 | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | Hydrolase, P-loop family; KEGG: efc:EFAU004_00653 3.2e-29 ATPase K06925; Psort location: Cytoplasmic, score: 7.50. | 0.481 |
fhs_3 | fgs_1 | HMPREF3229_01860 | HMPREF3229_00132 | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | 0.629 |
fhs_3 | folD | HMPREF3229_01860 | HMPREF3229_01526 | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
fhs_3 | guaA | HMPREF3229_01860 | HMPREF3229_00210 | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.758 |
fhs_3 | pabB | HMPREF3229_01860 | HMPREF3229_01211 | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | KEGG: ava:Ava_3468 3.2e-148 anthranilate synthase, component II K13950; Psort location: Cytoplasmic, score: 9.97. | 0.438 |
fhs_3 | sulD | HMPREF3229_01860 | HMPREF3229_00742 | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.484 |
folA | fgs_1 | HMPREF3229_00317 | HMPREF3229_00132 | KEGG: pce:PECL_916 1.1e-21 dfrA; dihydrofolate reductase; K00287 dihydrofolate reductase; Psort location: Cytoplasmic, score: 7.50. | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | 0.569 |
folA | pabB | HMPREF3229_00317 | HMPREF3229_01211 | KEGG: pce:PECL_916 1.1e-21 dfrA; dihydrofolate reductase; K00287 dihydrofolate reductase; Psort location: Cytoplasmic, score: 7.50. | KEGG: ava:Ava_3468 3.2e-148 anthranilate synthase, component II K13950; Psort location: Cytoplasmic, score: 9.97. | 0.422 |
folA | sulD | HMPREF3229_00317 | HMPREF3229_00742 | KEGG: pce:PECL_916 1.1e-21 dfrA; dihydrofolate reductase; K00287 dihydrofolate reductase; Psort location: Cytoplasmic, score: 7.50. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.554 |
folD | fgs_1 | HMPREF3229_01526 | HMPREF3229_00132 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Protein FolC; KEGG: csc:Csac_2037 5.5e-73 FolC bifunctional protein; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 7.50. | 0.592 |
folD | fhs_3 | HMPREF3229_01526 | HMPREF3229_01860 | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: faa:HMPREF0389_01605 1.2e-205 formate--tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 7.50. | 0.971 |