guaA protein (Peptoniphilus harei) - STRING interaction network

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Score

guaA

GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. (506 aa)

Predicted Functional Partners:

guaB

0.997

xpt

0.983

apt

0.981

purL

0.969

gmk_2

0.962

lysS

0.959

surE_3

0.953

hpt_1

0.951

pyrG

0.927

pheT

0.906

Your Current Organism:

Peptoniphilus harei

NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apt	gmk_2	HMPREF3229_01884	HMPREF3229_00946	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.945
apt	guaA	HMPREF3229_01884	HMPREF3229_00210	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	0.981
apt	hpt_1	HMPREF3229_01884	HMPREF3229_00228	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.923
apt	purL	HMPREF3229_01884	HMPREF3229_01479	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	KEGG: apr:Apre_1107 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97.	0.782
apt	pyrG	HMPREF3229_01884	HMPREF3229_00482	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.476
apt	surE_3	HMPREF3229_01884	HMPREF3229_00332	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.912
apt	xpt	HMPREF3229_01884	HMPREF3229_00421	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.922
gmk_2	apt	HMPREF3229_00946	HMPREF3229_01884	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.945
gmk_2	guaA	HMPREF3229_00946	HMPREF3229_00210	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	0.962
gmk_2	hpt_1	HMPREF3229_00946	HMPREF3229_00228	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.910
gmk_2	lysS	HMPREF3229_00946	HMPREF3229_00500	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	lysine--tRNA ligase; KEGG: fma:FMG_0987 2.5e-251 lysyl-tRNA synthetase class II; K04567 lysyl-tRNA synthetase, class II; Psort location: Cytoplasmic, score: 10.00; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.557
gmk_2	pheT	HMPREF3229_00946	HMPREF3229_00458	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: amt:Amet_1640 1.1e-193 pheT; phenylalanyl-tRNA synthetase subunit beta K01890; Psort location: Cytoplasmic, score: 9.97.	0.446
gmk_2	purL	HMPREF3229_00946	HMPREF3229_01479	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: apr:Apre_1107 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97.	0.697
gmk_2	surE_3	HMPREF3229_00946	HMPREF3229_00332	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.900
gmk_2	xpt	HMPREF3229_00946	HMPREF3229_00421	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.948
guaA	apt	HMPREF3229_00210	HMPREF3229_01884	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.981
guaA	gmk_2	HMPREF3229_00210	HMPREF3229_00946	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.962
guaA	guaB	HMPREF3229_00210	HMPREF3229_00427	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.997
guaA	hpt_1	HMPREF3229_00210	HMPREF3229_00228	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.951
guaA	lysS	HMPREF3229_00210	HMPREF3229_00500	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	lysine--tRNA ligase; KEGG: fma:FMG_0987 2.5e-251 lysyl-tRNA synthetase class II; K04567 lysyl-tRNA synthetase, class II; Psort location: Cytoplasmic, score: 10.00; Belongs to the class-II aminoacyl-tRNA synthetase family.	0.959