| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA31363.1 | apt | HMPREF3229_00477 | HMPREF3229_01884 | comF family protein; KEGG: ccm:Ccan_18380 1.7e-14 protein COM101A; Psort location: Cytoplasmic, score: 7.50. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.598 |
| KXA31363.1 | xpt | HMPREF3229_00477 | HMPREF3229_00421 | comF family protein; KEGG: ccm:Ccan_18380 1.7e-14 protein COM101A; Psort location: Cytoplasmic, score: 7.50. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.598 |
| apt | KXA31363.1 | HMPREF3229_01884 | HMPREF3229_00477 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | comF family protein; KEGG: ccm:Ccan_18380 1.7e-14 protein COM101A; Psort location: Cytoplasmic, score: 7.50. | 0.598 |
| apt | gmk_2 | HMPREF3229_01884 | HMPREF3229_00946 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.945 |
| apt | guaA | HMPREF3229_01884 | HMPREF3229_00210 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.981 |
| apt | hpt_1 | HMPREF3229_01884 | HMPREF3229_00228 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.923 |
| apt | punA | HMPREF3229_01884 | HMPREF3229_00784 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.940 |
| apt | purL | HMPREF3229_01884 | HMPREF3229_01479 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: apr:Apre_1107 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.782 |
| apt | surE_3 | HMPREF3229_01884 | HMPREF3229_00332 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
| apt | xpt | HMPREF3229_01884 | HMPREF3229_00421 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.922 |
| apt | ygfU | HMPREF3229_01884 | HMPREF3229_00882 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative permease; KEGG: apb:SAR116_1372 7.0e-57 xanthine/uracil permease K03458; Psort location: CytoplasmicMembrane, score: 10.00. | 0.469 |
| gmk_2 | apt | HMPREF3229_00946 | HMPREF3229_01884 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.945 |
| gmk_2 | guaA | HMPREF3229_00946 | HMPREF3229_00210 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.962 |
| gmk_2 | hpt_1 | HMPREF3229_00946 | HMPREF3229_00228 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.910 |
| gmk_2 | purL | HMPREF3229_00946 | HMPREF3229_01479 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | KEGG: apr:Apre_1107 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.97. | 0.697 |
| gmk_2 | surE_3 | HMPREF3229_00946 | HMPREF3229_00332 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| gmk_2 | xpt | HMPREF3229_00946 | HMPREF3229_00421 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.948 |
| guaA | apt | HMPREF3229_00210 | HMPREF3229_01884 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.981 |
| guaA | gmk_2 | HMPREF3229_00210 | HMPREF3229_00946 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.962 |
| guaA | guaB | HMPREF3229_00210 | HMPREF3229_00427 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.997 |