| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA29536.1 | KXA31589.1 | HMPREF3229_01160 | HMPREF3229_00311 | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | 0.889 |
| KXA29536.1 | dnaN | HMPREF3229_01160 | HMPREF3229_00723 | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.689 |
| KXA29536.1 | polA | HMPREF3229_01160 | HMPREF3229_00450 | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.994 |
| KXA29536.1 | recA | HMPREF3229_01160 | HMPREF3229_01159 | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.965 |
| KXA29536.1 | topA | HMPREF3229_01160 | HMPREF3229_00825 | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.713 |
| KXA31589.1 | KXA29536.1 | HMPREF3229_00311 | HMPREF3229_01160 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | 0.889 |
| KXA31589.1 | dnaN | HMPREF3229_00311 | HMPREF3229_00723 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.882 |
| KXA31589.1 | mutL | HMPREF3229_00311 | HMPREF3229_01174 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.541 |
| KXA31589.1 | polA | HMPREF3229_00311 | HMPREF3229_00450 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.991 |
| KXA31589.1 | recA | HMPREF3229_00311 | HMPREF3229_01159 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.847 |
| KXA31589.1 | sbcD | HMPREF3229_00311 | HMPREF3229_01204 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | Ser/Thr phosphatase family protein; KEGG: sax:USA300HOU_1836 3.9e-24 sbcD; DNA repair exonuclease; Psort location: Cytoplasmic, score: 7.50. | 0.889 |
| KXA31589.1 | topA | HMPREF3229_00311 | HMPREF3229_00825 | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.834 |
| dnaN | KXA29536.1 | HMPREF3229_00723 | HMPREF3229_01160 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ser/Thr phosphatase family protein; KEGG: bce:BC1857 2.3e-49 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 7.50. | 0.689 |
| dnaN | KXA31589.1 | HMPREF3229_00723 | HMPREF3229_00311 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50. | 0.882 |
| dnaN | mutL | HMPREF3229_00723 | HMPREF3229_01174 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.932 |
| dnaN | mutS_1 | HMPREF3229_00723 | HMPREF3229_01894 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | MutS domain V protein; KEGG: edi:EDI_294890 4.1e-23 DNA mismatch repair protein MSH2; Psort location: Cytoplasmic, score: 7.50. | 0.987 |
| dnaN | mutS_2 | HMPREF3229_00723 | HMPREF3229_01175 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.987 |
| dnaN | polA | HMPREF3229_00723 | HMPREF3229_00450 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.997 |
| dnaN | recA | HMPREF3229_00723 | HMPREF3229_01159 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.926 |
| dnaN | sbcD | HMPREF3229_00723 | HMPREF3229_01204 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ser/Thr phosphatase family protein; KEGG: sax:USA300HOU_1836 3.9e-24 sbcD; DNA repair exonuclease; Psort location: Cytoplasmic, score: 7.50. | 0.689 |
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