STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rsbWHypothetical protein; KEGG: cdl:CDR20291_3551 1.6e-09 rsbW; anti-sigma-B factor (serine-protein kinase); K04757 anti-sigma B factor; Psort location: Cytoplasmic, score: 7.50. (116 aa)    
Predicted Functional Partners:
rsbV
STAS domain protein; KEGG: ter:Tery_1523 1.4e-06 anti-sigma-factor antagonist and sugar transfersase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.998
sigB
Putative RNA polymerase sigma-B factor; KEGG: cpy:Cphy_2685 4.3e-25 RNA polymerase sigma 28 subunit FliA/WhiG K02405; Psort location: Cytoplasmic, score: 9.97; Belongs to the sigma-70 factor family.
  
 
 0.973
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.839
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
    0.827
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.818
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
     
 0.791
KXA30850.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.
       0.779
ybcJ
S4 domain protein YaaA; KEGG: fte:Fluta_1368 0.00028 ribosomal large subunit pseudouridine synthase B K06178; Psort location: Cytoplasmic, score: 7.50.
       0.762
rsbU
Stage II sporulation protein E; KEGG: awo:Awo_c16830 3.2e-22 phosphoserine phosphatase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.739
KXA28532.1
Iron-only hydrogenase maturation rSAM protein HydG; KEGG: hor:Hore_19320 1.2e-111 thiH; thiamine biosynthesis protein ThiH K03150; Psort location: Cytoplasmic, score: 7.50.
  
    0.621
Your Current Organism:
Peptoniphilus harei
NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.