STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (692 aa)    
Predicted Functional Partners:
leuS
leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.978
porA
KEGG: fma:FMG_0385 0. pyruvate/ferredoxin oxidoreductase; K03737 putative pyruvate-flavodoxin oxidoreductase; Psort location: Cytoplasmic, score: 7.50.
  
   0.968
smf
DNA protecting protein DprA; KEGG: ccm:Ccan_01460 1.2e-43 protein smf K04096; Psort location: Cytoplasmic, score: 7.50.
   
 0.953
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.950
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.854
KXA31589.1
DEAD2 domain protein; KEGG: cno:NT01CX_0936 6.3e-175 hypothetical protein; K10844 DNA excision repair protein ERCC-2; Psort location: Cytoplasmic, score: 7.50.
  
 0.834
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.829
KXA31238.1
Hypothetical protein; KEGG: bbu:BB_0259 0.0045 transglycosylase SLT domain protein; K08309 soluble lytic murein transglycosylase.
  
 
 0.827
ssb
KEGG: shn:Shewana3_3590 3.1e-15 single-strand binding protein K03111; Psort location: Cytoplasmic, score: 9.67.
  
 
 0.827
KXA28940.1
KEGG: shn:Shewana3_3590 2.0e-11 single-strand binding protein K03111; Psort location: Cytoplasmic, score: 9.67.
  
 
 0.827
Your Current Organism:
Peptoniphilus harei
NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.