| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA30452.1 | dtd | HMPREF3229_00915 | HMPREF3229_00919 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.502 |
| KXA30452.1 | hemZ_1 | HMPREF3229_00915 | HMPREF3229_00921 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | Coproporphyrinogen dehydrogenase HemZ; KEGG: cce:Ccel_1948 2.3e-67 coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97. | 0.552 |
| KXA30452.1 | queA | HMPREF3229_00915 | HMPREF3229_00912 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.623 |
| KXA30452.1 | recJ | HMPREF3229_00915 | HMPREF3229_00917 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | KEGG: cbe:Cbei_4321 1.8e-138 single-stranded-DNA-specific exonuclease RecJ; K07462 single-stranded-DNA-specific exonuclease; Psort location: Cytoplasmic, score: 7.50. | 0.506 |
| KXA30452.1 | relA | HMPREF3229_00915 | HMPREF3229_00918 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.463 |
| KXA30452.1 | speA | HMPREF3229_00915 | HMPREF3229_01814 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | Orn/Lys/Arg decarboxylase, major domain protein; KEGG: ttm:Tthe_0076 6.5e-70 Orn/Lys/Arg decarboxylase major subunit; K01582 lysine decarboxylase; Psort location: Cytoplasmic, score: 9.97. | 0.410 |
| KXA30452.1 | tgt | HMPREF3229_00915 | HMPREF3229_00913 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.623 |
| KXA30452.1 | yajC | HMPREF3229_00915 | HMPREF3229_00914 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | Preprotein translocase, YajC subunit; KEGG: apb:SAR116_0407 1.4e-10 YajC K03210. | 0.805 |
| KXA30452.1 | ydeM_3 | HMPREF3229_00915 | HMPREF3229_00916 | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | six-Cys-in-45 modification radical SAM protein; KEGG: mcj:MCON_2732 6.5e-15 anaerobic sulfatase-maturating protein K06871; Psort location: Cytoplasmic, score: 7.50. | 0.983 |
| dtd | KXA30452.1 | HMPREF3229_00919 | HMPREF3229_00915 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | 0.502 |
| dtd | hemZ_1 | HMPREF3229_00919 | HMPREF3229_00921 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Coproporphyrinogen dehydrogenase HemZ; KEGG: cce:Ccel_1948 2.3e-67 coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97. | 0.805 |
| dtd | queA | HMPREF3229_00919 | HMPREF3229_00912 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.461 |
| dtd | recJ | HMPREF3229_00919 | HMPREF3229_00917 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | KEGG: cbe:Cbei_4321 1.8e-138 single-stranded-DNA-specific exonuclease RecJ; K07462 single-stranded-DNA-specific exonuclease; Psort location: Cytoplasmic, score: 7.50. | 0.820 |
| dtd | relA | HMPREF3229_00919 | HMPREF3229_00918 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.875 |
| dtd | tgt | HMPREF3229_00919 | HMPREF3229_00913 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.426 |
| dtd | yajC | HMPREF3229_00919 | HMPREF3229_00914 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Preprotein translocase, YajC subunit; KEGG: apb:SAR116_0407 1.4e-10 YajC K03210. | 0.505 |
| dtd | ydeM_3 | HMPREF3229_00919 | HMPREF3229_00916 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | six-Cys-in-45 modification radical SAM protein; KEGG: mcj:MCON_2732 6.5e-15 anaerobic sulfatase-maturating protein K06871; Psort location: Cytoplasmic, score: 7.50. | 0.587 |
| hemZ_1 | KXA30452.1 | HMPREF3229_00921 | HMPREF3229_00915 | Coproporphyrinogen dehydrogenase HemZ; KEGG: cce:Ccel_1948 2.3e-67 coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97. | rSAM-modified six-cysteine peptide; Psort location: Extracellular, score: 8.91. | 0.552 |
| hemZ_1 | dtd | HMPREF3229_00921 | HMPREF3229_00919 | Coproporphyrinogen dehydrogenase HemZ; KEGG: cce:Ccel_1948 2.3e-67 coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.805 |
| hemZ_1 | queA | HMPREF3229_00921 | HMPREF3229_00912 | Coproporphyrinogen dehydrogenase HemZ; KEGG: cce:Ccel_1948 2.3e-67 coproporphyrinogen III oxidase; K02495 oxygen-independent coproporphyrinogen III oxidase; Psort location: Cytoplasmic, score: 9.97. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.432 |
