| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA28529.1 | rarA | HMPREF3229_01767 | HMPREF3229_00942 | Hypothetical protein; KEGG: pel:SAR11G3_00965 1.9e-24 guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase. | ATPase, AAA family; KEGG: ava:Ava_B0112 1.6e-105 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50. | 0.539 |
| KXA28529.1 | relA | HMPREF3229_01767 | HMPREF3229_00918 | Hypothetical protein; KEGG: pel:SAR11G3_00965 1.9e-24 guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase. | Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.549 |
| asnS | gmk_2 | HMPREF3229_00943 | HMPREF3229_00946 | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.657 |
| asnS | leuS | HMPREF3229_00943 | HMPREF3229_00944 | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.992 |
| asnS | nrdR | HMPREF3229_00943 | HMPREF3229_00941 | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.643 |
| asnS | rarA | HMPREF3229_00943 | HMPREF3229_00942 | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | ATPase, AAA family; KEGG: ava:Ava_B0112 1.6e-105 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50. | 0.659 |
| asnS | rsmB | HMPREF3229_00943 | HMPREF3229_00953 | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.576 |
| dnaN | rarA | HMPREF3229_00723 | HMPREF3229_00942 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATPase, AAA family; KEGG: ava:Ava_B0112 1.6e-105 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50. | 0.820 |
| dnaN | spoIIIE | HMPREF3229_00723 | HMPREF3229_01155 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative stage III sporulation protein E; KEGG: pen:PSEEN2212 4.0e-109 ftsK; cell division protein FtsK K03466; Psort location: CytoplasmicMembrane, score: 10.00. | 0.533 |
| gmk_2 | asnS | HMPREF3229_00946 | HMPREF3229_00943 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | 0.657 |
| gmk_2 | leuS | HMPREF3229_00946 | HMPREF3229_00944 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.619 |
| gmk_2 | nrdR | HMPREF3229_00946 | HMPREF3229_00941 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.416 |
| gmk_2 | rarA | HMPREF3229_00946 | HMPREF3229_00942 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | ATPase, AAA family; KEGG: ava:Ava_B0112 1.6e-105 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50. | 0.741 |
| gmk_2 | relA | HMPREF3229_00946 | HMPREF3229_00918 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.917 |
| gmk_2 | rsmB | HMPREF3229_00946 | HMPREF3229_00953 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.852 |
| leuS | asnS | HMPREF3229_00944 | HMPREF3229_00943 | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | asparagine--tRNA ligase; KEGG: ctx:Clo1313_2162 5.5e-176 asparaginyl-tRNA synthetase; K01893 asparaginyl-tRNA synthetase; Psort location: Cytoplasmic, score: 10.00. | 0.992 |
| leuS | gmk_2 | HMPREF3229_00944 | HMPREF3229_00946 | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.619 |
| leuS | nrdR | HMPREF3229_00944 | HMPREF3229_00941 | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.567 |
| leuS | rarA | HMPREF3229_00944 | HMPREF3229_00942 | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | ATPase, AAA family; KEGG: ava:Ava_B0112 1.6e-105 recombination factor protein RarA/unknown domain fusion protein K07478; Psort location: Cytoplasmic, score: 7.50. | 0.570 |
| leuS | rsmB | HMPREF3229_00944 | HMPREF3229_00953 | leucine--tRNA ligase; KEGG: fma:FMG_0623 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.656 |