gmk_2 protein (Peptoniphilus harei) - STRING interaction network

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Score

gmk_2

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)

Predicted Functional Partners:

guaA

0.962

xpt

0.948

apt

0.945

KXA30482.1

0.943

rpoZ

0.938

pyk

0.933

nrdA

0.920

relA

0.916

hpt_1

0.910

nrdB

0.906

Your Current Organism:

Peptoniphilus harei

NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXA30482.1	gmk_2	HMPREF3229_00945	HMPREF3229_00946	TIGR00255 family protein; KEGG: pfe:PSF113_5769 1.5e-29 yicC; protein YicC; Psort location: Cytoplasmic, score: 7.50.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.943
KXA30482.1	rpoZ	HMPREF3229_00945	HMPREF3229_00947	TIGR00255 family protein; KEGG: pfe:PSF113_5769 1.5e-29 yicC; protein YicC; Psort location: Cytoplasmic, score: 7.50.	DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.861
apt	gmk_2	HMPREF3229_01884	HMPREF3229_00946	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.945
apt	guaA	HMPREF3229_01884	HMPREF3229_00210	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	0.981
apt	hpt_1	HMPREF3229_01884	HMPREF3229_00228	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.923
apt	xpt	HMPREF3229_01884	HMPREF3229_00421	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.922
gmk_2	KXA30482.1	HMPREF3229_00946	HMPREF3229_00945	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	TIGR00255 family protein; KEGG: pfe:PSF113_5769 1.5e-29 yicC; protein YicC; Psort location: Cytoplasmic, score: 7.50.	0.943
gmk_2	apt	HMPREF3229_00946	HMPREF3229_01884	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.945
gmk_2	guaA	HMPREF3229_00946	HMPREF3229_00210	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	0.962
gmk_2	hpt_1	HMPREF3229_00946	HMPREF3229_00228	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.910
gmk_2	nrdA	HMPREF3229_00946	HMPREF3229_00747	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.920
gmk_2	nrdB	HMPREF3229_00946	HMPREF3229_00748	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.	0.906
gmk_2	pyk	HMPREF3229_00946	HMPREF3229_00289	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruvate kinase; KEGG: csc:Csac_1831 1.4e-163 pyruvate kinase; K00873 pyruvate kinase; Psort location: Cytoplasmic, score: 7.50.	0.933
gmk_2	relA	HMPREF3229_00946	HMPREF3229_00918	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Putative GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.916
gmk_2	rpoZ	HMPREF3229_00946	HMPREF3229_00947	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.938
gmk_2	xpt	HMPREF3229_00946	HMPREF3229_00421	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.948
guaA	apt	HMPREF3229_00210	HMPREF3229_01884	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.981
guaA	gmk_2	HMPREF3229_00210	HMPREF3229_00946	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.962
guaA	hpt_1	HMPREF3229_00210	HMPREF3229_00228	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	KEGG: ccb:Clocel_2100 3.0e-49 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.951
guaA	nrdA	HMPREF3229_00210	HMPREF3229_00747	GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.	Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.728