Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)    
Predicted Functional Partners:
exoA_2
Exodeoxyribonuclease III; KEGG: aur:HMPREF9243_1834 1.7e-108 xth; exodeoxyribonuclease III K01142; Psort location: Cytoplasmic, score: 9.97.
 
 0.995
nqrD
Electron transport complex, RnfABCDGE type, E subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.955
KXA30509.1
VanW-like protein; KEGG: mru:mru_1319 1.2e-05 DEAD/DEAH box helicase domain-containing protein; K03725 archaea-specific helicase.
       0.809
KXA30507.1
Hypothetical protein; KEGG: adg:Adeg_1704 3.0e-10 adenosylcobinamide-phosphate guanylyltransferase; Psort location: Cytoplasmic, score: 7.50.
       0.768
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.735
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.670
KXA31529.1
Electron transport complex, RnfABCDGE type, G subunit; KEGG: fma:FMG_1101 1.6e-09 sodium-translocating NADH-quinone reductase subunit C; K00348 Na+-transporting NADH:ubiquinone oxidoreductase subunit C.
  
  
 0.652
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 
 0.624
psuK
HTH domain protein; KEGG: cbj:H04402_01237 3.1e-70 pseudouridine kinase; Psort location: Cytoplasmic, score: 7.50.
  
    0.578
rnfB_2
Ferredoxin; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
  
  
 0.541
Your Current Organism:
Peptoniphilus harei
NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei
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