Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (222 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.964
dpnA_3
KEGG: cyj:Cyan7822_1878 2.6e-66 DNA methylase N-4/N-6 domain-containing protein; K07319 putative adenine-specific DNA-methyltransferase; Psort location: Cytoplasmic, score: 7.50; Belongs to the N(4)/N(6)-methyltransferase family.
    
 0.817
dinB_2
ImpB/MucB/SamB family protein; KEGG: ssr:SALIVB_0903 5.3e-162 dinB2; DNA polymerase IV 2 (Pol IV 2) K03502; Psort location: CytoplasmicMembrane, score: 8.16.
 
 
 0.762
dinB_1
ImpB/MucB/SamB family protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
  
 
 0.705
KXA29545.1
LysM domain protein; KEGG: tye:THEYE_A1300 0.0018 endopeptidase LytE; Psort location: CytoplasmicMembrane, score: 9.87.
  
  
 0.642
recN_1
DNA repair protein RecN; KEGG: apb:SAR116_2325 2.6e-57 ATPase K03631; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.614
rny
YmdA/YtgF family protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family.
     
 0.568
KXA29537.1
RecF/RecN/SMC protein; KEGG: bce:BC1852 1.2e-29 exonuclease SbcC K03546.
  
  
 0.528
KXA29539.1
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.528
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.519
Your Current Organism:
Peptoniphilus harei
NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei
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