node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | guaA | HMPREF3229_01815 | HMPREF3229_00210 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.623 |
birA | nadD | HMPREF3229_01815 | HMPREF3229_00112 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.479 |
birA | nrdR | HMPREF3229_01815 | HMPREF3229_00941 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.445 |
birA | ribBA | HMPREF3229_01815 | HMPREF3229_01427 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.813 |
birA | ribD | HMPREF3229_01815 | HMPREF3229_01429 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.748 |
birA | sulD | HMPREF3229_01815 | HMPREF3229_00742 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.780 |
gmk_1 | guaA | HMPREF3229_01430 | HMPREF3229_00210 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | 0.637 |
gmk_1 | ribBA | HMPREF3229_01430 | HMPREF3229_01427 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.765 |
gmk_1 | ribD | HMPREF3229_01430 | HMPREF3229_01429 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.715 |
gmk_1 | ribE | HMPREF3229_01430 | HMPREF3229_01428 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | KEGG: apr:Apre_1160 1.8e-51 riboflavin synthase subunit alpha; K00793 riboflavin synthase; Psort location: Cytoplasmic, score: 9.97. | 0.497 |
gmk_1 | ribH | HMPREF3229_01430 | HMPREF3229_01426 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.509 |
gmk_1 | rsmB | HMPREF3229_01430 | HMPREF3229_00953 | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.481 |
guaA | birA | HMPREF3229_00210 | HMPREF3229_01815 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.623 |
guaA | gmk_1 | HMPREF3229_00210 | HMPREF3229_01430 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Putative guanylate kinase; KEGG: sul:SYO3AOP1_0874 5.9e-21 gmk; guanylate kinase K00942; Psort location: Cytoplasmic, score: 9.97. | 0.637 |
guaA | ribBA | HMPREF3229_00210 | HMPREF3229_01427 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.809 |
guaA | ribD | HMPREF3229_00210 | HMPREF3229_01429 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.807 |
guaA | rsmB | HMPREF3229_00210 | HMPREF3229_00953 | GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.412 |
nadD | birA | HMPREF3229_00112 | HMPREF3229_01815 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.479 |
nadD | ribBA | HMPREF3229_00112 | HMPREF3229_01427 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.503 |
nadD | ribD | HMPREF3229_00112 | HMPREF3229_01429 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.724 |