| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXA28539.1 | KXA28540.1 | HMPREF3229_01777 | HMPREF3229_01778 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | Hypothetical protein; Displays ATPase and GTPase activities. | 0.937 |
| KXA28539.1 | murB_3 | HMPREF3229_01777 | HMPREF3229_01779 | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. | 0.761 |
| KXA28540.1 | KXA28539.1 | HMPREF3229_01778 | HMPREF3229_01777 | Hypothetical protein; Displays ATPase and GTPase activities. | Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. | 0.937 |
| KXA28540.1 | murB_3 | HMPREF3229_01778 | HMPREF3229_01779 | Hypothetical protein; Displays ATPase and GTPase activities. | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. | 0.776 |
| birA | murB_3 | HMPREF3229_01815 | HMPREF3229_01779 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. | 0.786 |
| ddl | mraY_2 | HMPREF3229_00255 | HMPREF3229_00934 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.691 |
| ddl | murAA | HMPREF3229_00255 | HMPREF3229_01533 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.649 |
| ddl | murB_3 | HMPREF3229_00255 | HMPREF3229_01779 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. | 0.946 |
| ddl | murC | HMPREF3229_00255 | HMPREF3229_00879 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.983 |
| ddl | murD | HMPREF3229_00255 | HMPREF3229_00935 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.840 |
| ddl | murE | HMPREF3229_00255 | HMPREF3229_00922 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; KEGG: faa:HMPREF0389_00596 1.8e-122 UDP-N-acetylmuramyl tripeptide synthetase; K01928 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Psort location: Cytoplasmic, score: 9.97. | 0.656 |
| ddl | murG | HMPREF3229_00255 | HMPREF3229_00937 | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.887 |
| mraY_2 | ddl | HMPREF3229_00934 | HMPREF3229_00255 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.691 |
| mraY_2 | murAA | HMPREF3229_00934 | HMPREF3229_01533 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.806 |
| mraY_2 | murB_3 | HMPREF3229_00934 | HMPREF3229_01779 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. | 0.764 |
| mraY_2 | murC | HMPREF3229_00934 | HMPREF3229_00879 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.904 |
| mraY_2 | murD | HMPREF3229_00934 | HMPREF3229_00935 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.991 |
| mraY_2 | murE | HMPREF3229_00934 | HMPREF3229_00922 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; KEGG: faa:HMPREF0389_00596 1.8e-122 UDP-N-acetylmuramyl tripeptide synthetase; K01928 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Psort location: Cytoplasmic, score: 9.97. | 0.872 |
| mraY_2 | murG | HMPREF3229_00934 | HMPREF3229_00937 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.976 |
| murAA | ddl | HMPREF3229_01533 | HMPREF3229_00255 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | D-ala D-ala ligase protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.649 |