Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
bioD1Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)    
Predicted Functional Partners:
bioA
KEGG: tva:TVAG_258770 2.2e-211 adenosylmethionine-8-amino-7-oxononanoate aminotransferase family protein; K00833 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.999
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 0.998
bioY
BioY family protein; KEGG: acl:ACL_0466 2.5e-18 birA; biotin-[acetyl-CoA-carboxylase] ligase K03523; Psort location: CytoplasmicMembrane, score: 10.00.
 
  
 0.888
KXA28533.1
Iron-only hydrogenase maturation rSAM protein HydE; KEGG: sri:SELR_19500 5.2e-84 hypothetical protein; K01012 biotin synthetase; Psort location: Cytoplasmic, score: 7.50.
  
  
 0.731
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.679
KXA27733.1
Haloacid dehalogenase-like hydrolase; KEGG: bcz:BCZK0296 1.9e-24 haloacid dehalogenase; K01091 phosphoglycolate phosphatase.
       0.552
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.516
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.498
sulD
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
     
 0.489
nadC_2
KEGG: fnu:FN0010 4.2e-91 nicotinate-nucleotide pyrophosphorylase K00767; Psort location: Cytoplasmic, score: 9.97; Belongs to the NadC/ModD family.
  
  
 0.482
Your Current Organism:
Peptoniphilus harei
NCBI taxonomy Id: 54005
Other names: ATCC BAA-601, CCUG 38491, CIP 105323, DSM 10020, NCTC 13076, P. harei, Peptostreptococcus harei, Schleiferella harei
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