node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ORS3428_00010 | ORS3428_00035 | ORS3428_00010 | ORS3428_00035 | Aminomethyltransferase; Belongs to the GcvT family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.905 |
ORS3428_00010 | ORS3428_00835 | ORS3428_00010 | ORS3428_00835 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.884 |
ORS3428_00010 | ORS3428_01990 | ORS3428_00010 | ORS3428_01990 | Aminomethyltransferase; Belongs to the GcvT family. | Methyltetrahydrofolate--corrinoid methyltransferase. | 0.874 |
ORS3428_00010 | ORS3428_02060 | ORS3428_00010 | ORS3428_02060 | Aminomethyltransferase; Belongs to the GcvT family. | Methionine synthase I. | 0.884 |
ORS3428_00010 | ORS3428_02965 | ORS3428_00010 | ORS3428_02965 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system protein T. | 0.893 |
ORS3428_00010 | folD | ORS3428_00010 | ORS3428_18580 | Aminomethyltransferase; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.904 |
ORS3428_00010 | gcvH | ORS3428_00010 | ORS3428_02960 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
ORS3428_00010 | gcvP | ORS3428_00010 | ORS3428_02955 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
ORS3428_00010 | thyA | ORS3428_00010 | ORS3428_01225 | Aminomethyltransferase; Belongs to the GcvT family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.883 |
ORS3428_00035 | ORS3428_00010 | ORS3428_00035 | ORS3428_00010 | Aminomethyltransferase; Belongs to the GcvT family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.905 |
ORS3428_00035 | ORS3428_00835 | ORS3428_00035 | ORS3428_00835 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.884 |
ORS3428_00035 | ORS3428_01990 | ORS3428_00035 | ORS3428_01990 | Aminomethyltransferase; Belongs to the GcvT family. | Methyltetrahydrofolate--corrinoid methyltransferase. | 0.873 |
ORS3428_00035 | ORS3428_02060 | ORS3428_00035 | ORS3428_02060 | Aminomethyltransferase; Belongs to the GcvT family. | Methionine synthase I. | 0.882 |
ORS3428_00035 | ORS3428_02965 | ORS3428_00035 | ORS3428_02965 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system protein T. | 0.900 |
ORS3428_00035 | folD | ORS3428_00035 | ORS3428_18580 | Aminomethyltransferase; Belongs to the GcvT family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.902 |
ORS3428_00035 | gcvH | ORS3428_00035 | ORS3428_02960 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
ORS3428_00035 | gcvP | ORS3428_00035 | ORS3428_02955 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
ORS3428_00035 | thyA | ORS3428_00035 | ORS3428_01225 | Aminomethyltransferase; Belongs to the GcvT family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.883 |
ORS3428_00835 | ORS3428_00010 | ORS3428_00835 | ORS3428_00010 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.884 |
ORS3428_00835 | ORS3428_00035 | ORS3428_00835 | ORS3428_00035 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.884 |