node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ORS3428_02965 | ORS3428_05055 | ORS3428_02965 | ORS3428_05055 | Glycine cleavage system protein T. | Dihydrolipoyl dehydrogenase. | 0.965 |
ORS3428_02965 | ORS3428_16285 | ORS3428_02965 | ORS3428_16285 | Glycine cleavage system protein T. | Dihydrolipoyl dehydrogenase. | 0.969 |
ORS3428_02965 | ORS3428_27520 | ORS3428_02965 | ORS3428_27520 | Glycine cleavage system protein T. | Dihydrolipoyl dehydrogenase. | 0.968 |
ORS3428_02965 | folD | ORS3428_02965 | ORS3428_18580 | Glycine cleavage system protein T. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.924 |
ORS3428_02965 | gcvH | ORS3428_02965 | ORS3428_02960 | Glycine cleavage system protein T. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
ORS3428_02965 | gcvP | ORS3428_02965 | ORS3428_02955 | Glycine cleavage system protein T. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
ORS3428_02965 | glyA | ORS3428_02965 | ORS3428_04055 | Glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
ORS3428_02965 | glyA-2 | ORS3428_02965 | ORS3428_26895 | Glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
ORS3428_02965 | glyA-3 | ORS3428_02965 | ORS3428_27140 | Glycine cleavage system protein T. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
ORS3428_02965 | thyA | ORS3428_02965 | ORS3428_01225 | Glycine cleavage system protein T. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.939 |
ORS3428_05055 | ORS3428_02965 | ORS3428_05055 | ORS3428_02965 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system protein T. | 0.965 |
ORS3428_05055 | ORS3428_16285 | ORS3428_05055 | ORS3428_16285 | Dihydrolipoyl dehydrogenase. | Dihydrolipoyl dehydrogenase. | 0.883 |
ORS3428_05055 | ORS3428_27520 | ORS3428_05055 | ORS3428_27520 | Dihydrolipoyl dehydrogenase. | Dihydrolipoyl dehydrogenase. | 0.889 |
ORS3428_05055 | folD | ORS3428_05055 | ORS3428_18580 | Dihydrolipoyl dehydrogenase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.418 |
ORS3428_05055 | gcvH | ORS3428_05055 | ORS3428_02960 | Dihydrolipoyl dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.945 |
ORS3428_05055 | gcvP | ORS3428_05055 | ORS3428_02955 | Dihydrolipoyl dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.978 |
ORS3428_05055 | glyA | ORS3428_05055 | ORS3428_04055 | Dihydrolipoyl dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.780 |
ORS3428_05055 | glyA-2 | ORS3428_05055 | ORS3428_26895 | Dihydrolipoyl dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.781 |
ORS3428_05055 | glyA-3 | ORS3428_05055 | ORS3428_27140 | Dihydrolipoyl dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.767 |
ORS3428_05055 | thyA | ORS3428_05055 | ORS3428_01225 | Dihydrolipoyl dehydrogenase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.551 |